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Literature DB >> 6622326

Renal elimination of amiodarone and its desethyl metabolite.

L Harris, C R Hind, W J McKenna, C Savage, S J Krikler, G C Storey, D W Holt.

Abstract

Two patients in chronic renal failure receiving amiodarone for the treatment of refractory arrhythmias were commenced on dialysis, in one case, intermittent peritoneal dialysis, in the other, haemodialysis. Plasma concentrations of amiodarone and its desethyl metabolite were consistent with the dose received, whilst neither compound was recovered in the dialysate. In these patients and in 10 additional patients with normal renal function taking amiodarone, only negligible amounts of either compound were detected in urine. These findings suggest that amiodarone may be a suitable antiarrhythmic agent for use in patients with chronic renal failure.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1983 PMID： 6622326 PMCID： PMC2417564 DOI： 10.1136/pgmj.59.693.440

Source DB: PubMed Journal: Postgrad Med J ISSN： 0032-5473 Impact factor: 2.401

12 in total

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Journal: Am J Cardiol Date: 1978-05-22 Impact factor: 2.778

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Authors: P Vérin; P Gendre; G Barchewitz; G Laurent-Bronchat; M Yacoubi; S Morax
Journal: Arch Ophtalmol Rev Gen Ophtalmol Date: 1971 Aug-Sep

3. [Research on the benzofuran series. XXXVII. Comparative study of transit and metabolism of amiodarone in different species of animals and humans].

Authors: J Broekhuysen; R Laruel; R Sion
Journal: Arch Int Pharmacodyn Ther Date: 1969-02

4. Dangers of amiodarone and anticoagulant treatment.

Authors: M J Serlin; R G Sibeon; G J Green
Journal: Br Med J (Clin Res Ed) Date: 1981-07-04

5. Possible association of pneumonitis with amiodarone therapy.

Authors: H H Rotmensch; M Liron; M Tupilski; S Laniado
Journal: Am Heart J Date: 1980-09 Impact factor: 4.749

6. Rapid high-performance liquid chromatographic method for the measurement of amiodarone in blood plasma or serum at the concentrations attained during therapy.

Authors: R J Flanagan; G C Storey; D W Holt
Journal: J Chromatogr Date: 1980-01-18

7. High-performance liquid chromatographic measurement of amiodarone and desethylamiodarone in plasma or serum at the concentrations attained following a single 400-mg dose.

Authors: G C Storey; D W Holt
Journal: J Chromatogr Date: 1982-08-27

8. Iodine-induced thyrotoxicosis in apparently normal thyroid glands.

Authors: J C Savoie; J P Massin; P Thomopoulos; F Leger
Journal: J Clin Endocrinol Metab Date: 1975-10 Impact factor: 5.958

Review 9. Iodide goiter and the pharmacologic effects of excess iodide.

Authors: J Wolff
Journal: Am J Med Date: 1969-07 Impact factor: 4.965

10. Clinical efficacy and electrophysiology during long-term therapy for recurrent ventricular tachycardia or ventricular fibrillation.

Authors: J J Heger; E N Prystowsky; W M Jackman; G V Naccarelli; K A Warfel; R L Rinkenberger; D P Zipes
Journal: N Engl J Med Date: 1981-09-03 Impact factor: 91.245

9 in total

Renal elimination of amiodarone and its desethyl metabolite.

Review 1. Pharmacokinetics of antiarrhythmic drugs.

2. [Corneal thesaurismosis due to amiodarone. Current data].

3. [Research on the benzofuran series. XXXVII. Comparative study of transit and metabolism of amiodarone in different species of animals and humans].

4. Dangers of amiodarone and anticoagulant treatment.

5. Possible association of pneumonitis with amiodarone therapy.

6. Rapid high-performance liquid chromatographic method for the measurement of amiodarone in blood plasma or serum at the concentrations attained during therapy.

7. High-performance liquid chromatographic measurement of amiodarone and desethylamiodarone in plasma or serum at the concentrations attained following a single 400-mg dose.

8. Iodine-induced thyrotoxicosis in apparently normal thyroid glands.

Review 9. Iodide goiter and the pharmacologic effects of excess iodide.

10. Clinical efficacy and electrophysiology during long-term therapy for recurrent ventricular tachycardia or ventricular fibrillation.

Review 1. Amiodarone: the experience of the past decade.

2. Pharmacokinetics of amiodarone, desethylamiodarone and other iodine-containing amiodarone metabolites.

Review 3. Clinical pharmacokinetics of amiodarone.

Review 4. Clinical pharmacokinetics of the newer antiarrhythmic agents.

Review 5. Class III antiarrhythmics in overdose. Presenting features and management principles.

6. Modeling of Amiodarone Effect on Heart Rate Control in Critically Ill Patients with Atrial Tachyarrhythmias.

7. Amiodarone pharmacokinetics. I. Acute dose-dependent disposition studies in rats.

Review 8. Clinical and Mechanistic Review of Amiodarone-Associated Optic Neuropathy.

Review 9. Drug therapy in haemodialysis patients. Special considerations in the elderly.