Literature DB >> 6622214

Org 4333, a potent, irreversibly binding estrogen agonist.

A J van den Broek, J Leemhuis, M S de Winter, F J Zeelen.   

Abstract

Two synthetic routes to 11 beta-chloromethylestra-1,3,5(10)-trien-3,17 beta-diol (Org 4333) are described. In biological tests this compound was found to be a potent irreversibly binding estrogen agonist.

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Year:  1983        PMID： 6622214     DOI： 10.1007/bf01961478

Source DB:  PubMed          Journal:  Pharm Weekbl Sci        ISSN： 0167-6555


  3 in total

1.  The synthesis and study of some potential affinity labeling reagents for estrogen receptors.

Authors:  T Ratajczak; P N Sheppard; R J Capon; R Hähnel
Journal:  Steroids       Date:  1981-11       Impact factor: 2.668

2.  Strategy in drug research. Synthesis and study of the progestational and ovulation inhibitory activity of a series of 11beta-substituted-17alpha-ethynyl-4-estren-17beta-ols.

Authors:  A J Broek; A I Broess; M J Heuvel; H P de Jongh; J Leemhuis; K H Schönemann; J Smits; J de Visser; N P van Vliet; F J Zeelen
Journal:  Steroids       Date:  1977-10       Impact factor: 2.668

3.  Tamoxifen aziridines: effective inactivators of the estrogen receptor.

Authors:  D W Robertson; L L Wei; J R Hayes; K E Carlson; J A Katzenellenbogen; B S Katzenellenbogen
Journal:  Endocrinology       Date:  1981-10       Impact factor: 4.736
  3 in total
  1 in total

1.  A mutant form of ERα associated with estrogen insensitivity affects the coupling between ligand binding and coactivator recruitment.

Authors:  Yin Li; Laurel A Coons; René Houtman; Kathryn E Carlson; Teresa A Martin; Christopher G Mayne; Diana Melchers; Tanner B Jefferson; J Tyler Ramsey; John A Katzenellenbogen; Kenneth S Korach
Journal:  Sci Signal       Date:  2020-09-22       Impact factor: 8.192
  1 in total

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