Literature DB >> 6621485

Cyst and host tissue concentrations of mebendazole in patients undergoing surgery for hydatid disease.

P A Braithwaite, R J Allan, M Dawson, M S Roberts, T R Watson.   

Abstract

Mebendazole levels were assayed by high performance liquid chromatographic assay in plasma, host tissues, and hydatid material taken from four patients who underwent surgery for hydatid disease. The drug was absorbed and had penetrated both into the host and into the parasite material. The levels of the drug in viable hydatid cysts were much lower than those in dead cysts. The possibility of exclusion or detoxification of the drug by viable hydatid cysts is raised.

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Year:  1983        PMID: 6621485     DOI: 10.5694/j.1326-5377.1983.tb122534.x

Source DB:  PubMed          Journal:  Med J Aust        ISSN: 0025-729X            Impact factor:   7.738


  2 in total

1.  A correlation between serum mebendazole concentrations and the aminopyrine breath test. Implications in the treatment of hydatid disease.

Authors:  A Bekhti; J Pirotte; R Woestenborghs
Journal:  Br J Clin Pharmacol       Date:  1986-02       Impact factor: 4.335

2.  Treatment of cystic echinococcosis (Echinococcus granulosus) with mebendazole: assessment of bound and free drug levels in cyst fluid and of parasite vitality in operative specimens.

Authors:  P J Luder; F Witassek; K Weigand; J Eckert; J Bircher
Journal:  Eur J Clin Pharmacol       Date:  1985       Impact factor: 2.953

  2 in total

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