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Literature DB >> 6620333

Phenazopyridine induced methaemoglobinaemia associated with decreased activity of erythrocyte cytochrome b5 reductase.

Abstract

A 25-year-old woman taking usual doses of phenazopyridine developed her third clinically significant episode of cyanosis. Life threatening methaemoglobinaemia was documented and was treated with methylene blue. The patient and several members of her family showed decreased activities of erythrocyte NADH-cytochrome b5 reductase, predisposing them to the development of clinically significant methaemoglobinaemia when challenged with oxidant drugs.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1983 PMID： 6620333 PMCID： PMC1049126 DOI： 10.1136/jmg.20.4.307

Source DB: PubMed Journal: J Med Genet ISSN： 0022-2593 Impact factor: 6.318

10 in total

1. METHEMOGLOBINEMIA AND HEINZ BODY HEMOLYTIC ANEMIA DUE TO PHENAZOPYRIDINE HYDROCHLORIDE.

Authors: M S GREENBERG; H WONG
Journal: N Engl J Med Date: 1964-08-27 Impact factor: 91.245

2. The relation of diaphorase of human erythrocytes to inheritance of methemoglobinemia.

Authors: E M SCOTT
Journal: J Clin Invest Date: 1960-07 Impact factor: 14.808

3. Methemoglobinemia associated with pyridium administration; report of a case.

Authors: S E CRAWFORD; A E MOON; T C PANOS; C A HOOKS
Journal: J Am Med Assoc Date: 1951-05-05

Review 4. Drug-induced methemoglobinemia.

Authors: R P Smith; M V Olson
Journal: Semin Hematol Date: 1973-07 Impact factor: 3.851

5. Catalysis of methaemoglobin reduction by erythrocyte cytochrome B5 and cytochrome B5 reductase.

Authors: D E Hultquist; P G Passon
Journal: Nat New Biol Date: 1971-02-24

6. A simple method for the detection of unstable haemoglobins.

Authors: R W Carrell; R Kay
Journal: Br J Haematol Date: 1972-11 Impact factor: 6.998

7. New method for determining ferrihemoglobin reductase (NADH-methemoglobin reductase) in erythrocytes.

Authors: E Hegesh; N Calmanovici; M Avron
Journal: J Lab Clin Med Date: 1968-08

Review 8. Methaemoglobinaemia.

Authors: E R Jaffé
Journal: Clin Haematol Date: 1981-02

9. Methemoglobinemia from sniffing butyl nitrite.

Authors: M K Horne; M R Waterman; L M Simon; J C Garriott; E H Foerster
Journal: Ann Intern Med Date: 1979-09 Impact factor: 25.391

10. Syndrome of bilateral pheochromocytoma, medullary thyroid carcinoma and multiple neuromas. A possible regulatory defect in the differentiation of chromaffin tissue.

Authors: R N Schimke; W H Hartmann; T E Prout; D L Rimoin
Journal: N Engl J Med Date: 1968-07-04 Impact factor: 91.245

10 in total

6 in total

Phenazopyridine induced methaemoglobinaemia associated with decreased activity of erythrocyte cytochrome b5 reductase.

1. METHEMOGLOBINEMIA AND HEINZ BODY HEMOLYTIC ANEMIA DUE TO PHENAZOPYRIDINE HYDROCHLORIDE.

2. The relation of diaphorase of human erythrocytes to inheritance of methemoglobinemia.

3. Methemoglobinemia associated with pyridium administration; report of a case.

Review 4. Drug-induced methemoglobinemia.

5. Catalysis of methaemoglobin reduction by erythrocyte cytochrome B5 and cytochrome B5 reductase.

6. A simple method for the detection of unstable haemoglobins.

7. New method for determining ferrihemoglobin reductase (NADH-methemoglobin reductase) in erythrocytes.

Review 8. Methaemoglobinaemia.

9. Methemoglobinemia from sniffing butyl nitrite.

10. Syndrome of bilateral pheochromocytoma, medullary thyroid carcinoma and multiple neuromas. A possible regulatory defect in the differentiation of chromaffin tissue.

Review 1. Haematological effects of non-narcotic analgesics.

2. PharmGKB summary: methylene blue pathway.

Review 3. PharmGKB summary: uric acid-lowering drugs pathway, pharmacodynamics.

4. Acquired methemoglobinemia from phenazopyridine use.

5. Drug-induced hematologic syndromes.

6. A Rare but Important Clinical Presentation of Induced Methemoglobinemia.