| Literature DB >> 6620143 |
V K Batra, J A Morrison, T R Hoffman.
Abstract
Piperacillin sodium was administered intravenously to dogs, alone or in combination with gentamicin, twice a day (approximately 5 hr apart) for 36-37 days. The pharmacokinetics of neither drug changed in the presence of the other; however, the percentage of the gentamicin dose recovered in the urine decreased significantly when coadministered with piperacillin. The data demonstrate that interaction between the two drugs in urine is feasible.Entities:
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Year: 1983 PMID： 6620143 DOI： 10.1002/jps.2600720813
Source DB: PubMed Journal: J Pharm Sci ISSN： 0022-3549 Impact factor: 3.534