Literature DB >> 6619887

Catharanthus alkaloids XXXVII. 16-Epi-Z-isositsirikine, a monomeric indole alkaloid with antineoplastic activity from Catharanthus roseus and Rhazya stricta.

S Mukhopadhyay, A El-Sayed, G A Handy, G A Cordell.   

Abstract

16-Epi-Z-isositsirikine (1) has been isolated from the leaves of Catharanthus roseus and Rhazya stricta and identified through a combination of spectral interpretation and chemical correlation. The compound displayed antineoplastic activity in the KB test system in vitro and the P-388 test system in vivo.

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Year:  1983        PMID： 6619887     DOI： 10.1021/np50027a019

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  4 in total

1.  Aza-tryptamine substrates in monoterpene indole alkaloid biosynthesis.

Authors:  Hyang-Yeol Lee; Nancy Yerkes; Sarah E O'Connor
Journal:  Chem Biol       Date:  2009-12-24

2.  In vitro induction of human embryonal carcinoma differentiation by a crude extract of Rhazya stricta.

Authors:  Faisal S Alagrafi; Abdullah O Alawad; Nael M Abutaha; Fahd A Nasr; Othman A Alhazzaa; Sultan N Alharbi; Mohammad N Alkhrayef; Mohamed Hammad; Ziyad A Alhamdan; Abdullah D Alenazi; Mohammad A Wadaan
Journal:  BMC Complement Altern Med       Date:  2017-06-29       Impact factor: 3.659

3.  Crude alkaloid extract of Rhazya stricta inhibits cell growth and sensitizes human lung cancer cells to cisplatin through induction of apoptosis.

Authors:  Ayman I Elkady
Journal:  Genet Mol Biol       Date:  2013-03-04       Impact factor: 1.771

4.  Phytochemical and taxonomic evaluation of Rhazya stricta in Saudi Arabia.

Authors:  Najat A Bukhari; Reem A Al-Otaibi; Mohammed M Ibhrahim
Journal:  Saudi J Biol Sci       Date:  2015-11-10       Impact factor: 4.219
  4 in total

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