Literature DB >> 6618794

Involvement of the pineal gland in rats with experimental autoimmune uveitis.

M Mochizuki, J Charley, T Kuwabara, R B Nussenblatt, I Gery.   

Abstract

Pineal glands of rats with experimentally induced autoimmune uveitis (EAU) were studied histologically. Inflammatory changes, characterized by mononuclear infiltration, were found in the pineal glands of one-third of the Lewis rats that developed EAU by active immunization with S-antigen. No changes in the pineal gland were observed in AVN rats which are "low responders" for EAU and did not develop ocular disease. Frequency and severity of both pineal gland and ocular involvement clearly were elevated by intravenous injection of Bordetella pertussis along with the S-antigen immunization; all B. pertussis-treated rats of both Lewis and AVN strains developed pineal and ocular changes. Inflammatory changes of the pineal gland also were found in rats in which EAU was induced passively by transfer of lymphocytes from S-antigen-immunized donors. The frequency of involvement of the pineal gland was found to be lower than that of the retinas in rats where EAU was induced by active immunization or by adoptive transfer of lymphocytes.

Entities:  

Mesh：

Year:  1983        PMID： 6618794

Source DB:  PubMed          Journal:  Invest Ophthalmol Vis Sci        ISSN： 0146-0404            Impact factor:   4.799


  9 in total

1.  A novel inflammatory eye disease induced by lymphocytes from knockout mice sensitized against the deleted ocular antigen.

Authors:  M P Gelderman; P Charukamnoetkanok; J P Brady; L Hung; J S Zigler; E F Wawrousek; B P Vistica; E Fortin; C-C Chan; I Gery
Journal:  Clin Exp Immunol       Date:  2003-08       Impact factor: 4.330

2.  The effect of retinal S-antigen-specific monoclonal antibody therapy on experimental autoimmune uveoretinitis (EAU) and experimental autoimmune pinealitis (EAP).

Authors:  H S Dua; H F Sewell; J V Forrester
Journal:  Clin Exp Immunol       Date:  1989-01       Impact factor: 4.330

3.  Effects of continuous light exposure on the rat retina and pineal gland.

Authors:  M Mochizuki; T Kuwabara; I Gery
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1988       Impact factor: 3.117

4.  Elevated prolactin levels in human aqueous humor of patients with anterior uveitis.

Authors:  U Pleyer; D Gupta; E G Weidle; W Lisch; M Zierhut; H J Thiel
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1991       Impact factor: 3.117

5.  Pinealitis accompanying equine recurrent uveitis.

Authors:  C M Kalsow; A E Dwyer; A W Smith; T P Nifong
Journal:  Br J Ophthalmol       Date:  1993-01       Impact factor: 4.638

6.  Neuroendocrine alterations in uveitis patients.

Authors:  H A Wollmann; U Pleyer; S Friedel; M Zierhut; H J Thiel; D Gupta
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1994-05       Impact factor: 3.117

7.  Prevention of experimental autoimmune uveoretinitis and experimental autoimmune pinealitis in (Lewis x Brown-Norway) F1 rats by HgCl2 injections.

Authors:  A Saoudi; B Bellon; Y de Kozak; J Kuhn; M C Vial; B Thillaye; P Druet
Journal:  Immunology       Date:  1991-10       Impact factor: 7.397

8.  Active induction of experimental autoimmune encephalomyelitis by MOG35-55 peptide immunization is associated with differential responses in separate compartments of the choroid plexus.

Authors:  Nivetha Murugesan; Debayon Paul; Yen Lemire; Bandana Shrestha; Shujun Ge; Joel S Pachter
Journal:  Fluids Barriers CNS       Date:  2012-08-07

9.  Identification of an immunodominant and highly immunopathogenic determinant in the retinal interphotoreceptor retinoid-binding protein (IRBP).

Authors:  H Sanui; T M Redmond; S Kotake; B Wiggert; L H Hu; H Margalit; J A Berzofsky; G J Chader; I Gery
Journal:  J Exp Med       Date:  1989-06-01       Impact factor: 14.307
  9 in total

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