Literature DB >> 661815

Metabolism of trans-9,10-dihydroxy-9,10-dihydrobenzo[a]pyrene occurs primarily by arylhydroxylation rather than formation of a diol epoxide.

D R Thakker, H Yagi, R E Lehr, W Levin, M Buening, A Y Lu, R L Chang, A W Wood, A H Conney, D M Jerina.   

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Year:  1978        PMID： 661815

Source DB:  PubMed          Journal:  Mol Pharmacol        ISSN： 0026-895X            Impact factor:   4.436


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  6 in total

1.  Analysis of phenanthrene and benzo[a]pyrene tetraol enantiomers in human urine: relevance to the bay region diol epoxide hypothesis of benzo[a]pyrene carcinogenesis and to biomarker studies.

Authors:  Stephen S Hecht; Steven G Carmella; Peter W Villalta; J Bradley Hochalter
Journal:  Chem Res Toxicol       Date:  2010-05-17       Impact factor: 3.739

2.  Functional characterization of human cytochrome P450 2S1 using a synthetic gene-expressed protein in Escherichia coli.

Authors:  Peter H Bui; Oliver Hankinson
Journal:  Mol Pharmacol       Date:  2009-08-27       Impact factor: 4.436

3.  Quantitation of enantiomers of r-7,t-8,9,c-10-tetrahydroxy-7,8,9,10-tetrahydrobenzo[a]-pyrene in human urine: evidence supporting metabolic activation of benzo[a]pyrene via the bay region diol epoxide.

Authors:  Stephen S Hecht; Jon Bradley Hochalter
Journal:  Mutagenesis       Date:  2014-07-21       Impact factor: 3.000

4.  Specificity of chemiluminescence in the metabolism of benzo[a]pyrene to its carcinogenic diol epoxide.

Authors:  J P Hamman; H H Seliger; G H Posner
Journal:  Proc Natl Acad Sci U S A       Date:  1981-02       Impact factor: 11.205

5.  Metabolic conversion of dibenz[a,h]anthracene (+/-)trans-1,2-dihydrodiol and chrysene (+/-)trans-3,4-dihydrodiol to vicinal dihydrodiol epoxides.

Authors:  M W Chou; P P Fu; S K Yang
Journal:  Proc Natl Acad Sci U S A       Date:  1981-07       Impact factor: 11.205

6.  Fungal oxidation of (+/-)-9,10-dihydroxy-9,10-dihydrobenzo[a]pyrene: formation of diastereomeric benzo[a]pyrene 9,10-diol 7,8-epoxides.

Authors:  C E Cerniglia; D T Gibson
Journal:  Proc Natl Acad Sci U S A       Date:  1980-08       Impact factor: 11.205
  6 in total

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