Literature DB >> 6618148

The effect of peripherally administered GABA on spontaneous contractions of rat urinary bladder in vivo.

C A Maggi, P Santicioli, G Grimaldi, A Meli.   

Abstract

Intravenous GABA suppresses the spontaneous contractions of rat urinary bladder produced by saline loading (micturition reflex) without possessing any significant inhibitory effect on spontaneous and stimulated (neuro-hormones and field stimulation) contraction of rat detrusor strips in vitro. The in vivo effects of GABA, in view of the results obtained with atropine, hexamethonium and tetrodotoxin in the same experimental conditions, are likely to be ascribable to an action at pelvic ganglia level.

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Year:  1983        PMID： 6618148     DOI： 10.1016/0306-3623(83)90029-0

Source DB:  PubMed          Journal:  Gen Pharmacol        ISSN： 0306-3623


  6 in total

Review 1.  CNS involvement in overactive bladder: pathophysiology and opportunities for pharmacological intervention.

Authors:  Karl-Erik Andersson; Rikard Pehrson
Journal:  Drugs       Date:  2003       Impact factor: 9.546

2.  The effects of baclofen on spinal and supraspinal micturition reflexes in rats.

Authors:  C A Maggi; P Santicioli; S Giuliani; M Furio; B Conte; P Meli; L Gragnani; A Meli
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-08       Impact factor: 3.000

3.  Localization of L-glutamate decarboxylase immunoreactivity in the major pelvic ganglion and in the coeliac-superior mesenteric ganglion complex of the rat.

Authors:  T Karhula; O Häppölä; T Joh; J Y Wu
Journal:  Histochemistry       Date:  1988

4.  Regulation of the substance P-induced contraction via the release of acetylcholine and gamma-aminobutyric acid in the guinea-pig urinary bladder.

Authors:  J Shirakawa; T Nakanishi; K Taniyama; S Kamidono; C Tanaka
Journal:  Br J Pharmacol       Date:  1989-10       Impact factor: 8.739

5.  The effect of nifedipine and verapamil on KC1-induced rhythmic contractions of guinea pig ureter in vitro.

Authors:  C A Maggi; A Meli
Journal:  Experientia       Date:  1984-07-15

6.  Differences in cardiovascular responses to peripherally administered GABA as influenced by basal conditions and type of anaesthesia.

Authors:  S Giuliani; C A Maggi; A Meli
Journal:  Br J Pharmacol       Date:  1986-07       Impact factor: 8.739
  6 in total

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