Literature DB >> 6617819

Effects of neurochemical lesions restricted to spinal cord monoaminergic neurons on blood pressure and sympathetic activity of spontaneously hypertensive rats.

M O Carruba, H H Keller, M Da Prada.   

Abstract

Intraspinal (i.s.) injection of 6-hydroxydopamine or 5,7-dihydroxytryptamine in newborn spontaneously hypertensive rats (SHR) resulted, in the adult animal (30-week-old), in a marked decrease of spinal cord noradrenaline (NA) or 5-hydroxytryptamine (5-HT) levels, respectively. Since both neurotoxin- and vehicle-injected rats developed full hypertension and had similar plasma catecholamine concentrations, it is concluded that in SHR neither spinal cord NA nor 5-HT play a major role in development and maintenance of hypertension.

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Year:  1983        PMID： 6617819     DOI： 10.1007/bf01943165

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  20 in total

Review 1.  Current status of dopamine in the mammalian spinal cord.

Authors:  J W Commissiong; N H Neff
Journal:  Biochem Pharmacol       Date:  1979-05-15       Impact factor: 5.858

2.  Role of central and peripheral adrenergic mechanisms in neurogenic hypertension produced by brainstem lesions in rat.

Authors:  N Doba; D J Reis
Journal:  Circ Res       Date:  1974-03       Impact factor: 17.367

3.  The importance of central adrenergic neurones in renal hypertension in rabbits.

Authors:  J P Chalmers; C T Dollery; P J Lewis; J L Reid
Journal:  J Physiol       Date:  1974-04       Impact factor: 5.182

4.  Participation of central noradrenergic neurons in arterial baroreceptor reflexes in the rabbit. A study with intracisternally administered 6-hydroxydopamine.

Authors:  J P Chalmers; J L Reid
Journal:  Circ Res       Date:  1972-11       Impact factor: 17.367

5.  Long-lasting depletion of spinal cord 5-hydroxytryptamine or catecholamines after intraspinal injection of 5,7-dihydroxytryptamine or 6-hydroxydopamine to newborn rats.

Authors:  M O Carruba; H H Keller; M Da Prada
Journal:  Neurosci Lett       Date:  1983-02-21       Impact factor: 3.046

6.  Quantitative localization of biogenic amines in the spinal cord.

Authors:  J A Zivin; J L Reid; J M Saavedra; I J Kopin
Journal:  Brain Res       Date:  1975-12-05       Impact factor: 3.252

7.  Effect of intracerebroventricular 5,6-dihydroxytryptamine on blood pressure of spontaneously hypertensive rats.

Authors:  R E Buckingham; T C Hamilton; D Robson
Journal:  Eur J Pharmacol       Date:  1976-04       Impact factor: 4.432

8.  Effects of intraventricular and intraspinal 6-hydroxydopamine on blood pressure of apontaneously hypertensive rats.

Authors:  T Kubo; M Hashimoto
Journal:  Arch Int Pharmacodyn Ther       Date:  1978-03

9.  Involvement of serotonin in the central regulation of blood pressure: evidence for a facilitating effect on sympathetic nerve activity.

Authors:  R B McCall; S J Humphrey
Journal:  J Pharmacol Exp Ther       Date:  1982-07       Impact factor: 4.030

10.  Neonatal intraspinal 6-hydroxydopamine: depletion of norepinephrine but not dopamine.

Authors:  R Ings; B Pappas
Journal:  Eur J Pharmacol       Date:  1981-04-09       Impact factor: 4.432
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  1 in total

1.  Catecholamines and serotonin in the rat central nervous system after 6-OHDA, 5-7-DHT and p-CPA.

Authors:  T A Reader; P Gauthier
Journal:  J Neural Transm       Date:  1984       Impact factor: 3.575
  1 in total

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