Bromsulphalein plasma kinetics after obstruction of the common bile duct in rats: curve fitting with a programmable calculator.

Plasma kinetics of bromsulphalein (BSP) after a single injection into the bloodstream of the rat with total obstruction of the common bile duct was examined. The concentrations of BSP were determined colorimetrically. A monoexponential plus a general first-degree function in time with four unknown parameters was fitted. Two programs were developed for the Texas Instruments 59 programmable calculator to estimate the values of all the parameters by an iteration procedure. The programs executed at about twice normal speed.