| Literature DB >> 6617075 |
B Mellström, L Bertilsson, Y C Lou, J Säwe, F Sjöqvist.
Abstract
Amitriptyline AT demethylation to nortriptyline NT was determined in nine healthy subjects who had been phenotyped with respect to debrisoquine D hydroxylation capacity. AT demethylation was calculated from the ratio between the plasma AUCs of NT after single oral doses of AT and NT. Plasma clearance of AT by demethylation did not correlate with the ratio between D and 4-hydroxy-D in urine (rs = -0.55).Entities:
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Year: 1983 PMID： 6617075 DOI： 10.1038/clpt.1983.207
Source DB: PubMed Journal: Clin Pharmacol Ther ISSN： 0009-9236 Impact factor: 6.875