Literature DB >> 6616473

Gastrin-releasing peptide-related peptides in a human malignant lung carcinoid tumor.

K A Roth, C J Evans, E Weber, J D Barchas, D G Bostwick, K G Bensch.   

Abstract

Recent immunohistochemical findings have indicated the presence of gastrin-releasing peptide in normal and pathological human lungs. Gastrin-releasing peptide is a 27-amino acid peptide isolated from porcine gut which bears considerable carboxyterminal homology with bombesin. We have characterized the gastrin-releasing peptide-like peptides present in a human malignant lung carcinoid tumor by gel chromatography and reverse-phase high-performance liquid chromatography. Our results show that this tumor did not contain bombesin; however, this tumor expressed a gastrin-releasing peptide-like compound, several amino-terminal fragments, and a carboxy-terminal fragment of gastrin-releasing peptide.

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Year:  1983        PMID： 6616473

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  9 in total

1.  Co-secretion of calcitonin gene-related peptide, gastrin-releasing peptide and ACTH by a carcinoid tumour metastasizing to the cerebellum.

Authors:  M A Ghatei; M R Stratton; J M Allen; G F Joplin; J M Polak; S R Bloom
Journal:  Postgrad Med J       Date:  1987-02       Impact factor: 2.401

2.  Bronchial carcinoids: an analysis of 91 cases.

Authors:  H Mårtensson; G Böttcher; G Hambraeus; F Sundler; H Willen; A Nobin
Journal:  World J Surg       Date:  1987-06       Impact factor: 3.352

3.  Gastrin-releasing peptide, a mammalian analog of bombesin, is present in human neuroendocrine lung tumors.

Authors:  D G Bostwick; K A Roth; C J Evans; J D Barchas; K G Bensch
Journal:  Am J Pathol       Date:  1984-11       Impact factor: 4.307

4.  A rhesus monkey model to characterize the role of gastrin-releasing peptide (GRP) in lung development. Evidence for stimulation of airway growth.

Authors:  K Li; S R Nagalla; E R Spindel
Journal:  J Clin Invest       Date:  1994-10       Impact factor: 14.808

5.  Diverse clinical and pathologic features of gastric carcinoid and the relevance of hypergastrinemia.

Authors:  D B Gough; G B Thompson; T B Crotty; J H Donohue; L K Kvols; J A Carney; C S Grant; D M Nagorney
Journal:  World J Surg       Date:  1994 Jul-Aug       Impact factor: 3.352

6.  High-affinity receptors for peptides of the bombesin family in Swiss 3T3 cells.

Authors:  I Zachary; E Rozengurt
Journal:  Proc Natl Acad Sci U S A       Date:  1985-11       Impact factor: 11.205

7.  Cloning and characterization of cDNAs encoding human gastrin-releasing peptide.

Authors:  E R Spindel; W W Chin; J Price; L H Rees; G M Besser; J F Habener
Journal:  Proc Natl Acad Sci U S A       Date:  1984-09       Impact factor: 11.205

8.  Internalization and degradation of peptides of the bombesin family in Swiss 3T3 cells occurs without ligand-induced receptor down-regulation.

Authors:  I Zachary; E Rozengurt
Journal:  EMBO J       Date:  1987-08       Impact factor: 11.598

9.  Early events elicited by bombesin and structurally related peptides in quiescent Swiss 3T3 cells. I. Activation of protein kinase C and inhibition of epidermal growth factor binding.

Authors:  I Zachary; J W Sinnett-Smith; E Rozengurt
Journal:  J Cell Biol       Date:  1986-06       Impact factor: 10.539
  9 in total

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