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Literature DB >> 6616439

i(12p): specific chromosomal marker in seminoma and malignant teratoma of the testis?

Abstract

A similar small marker chromosome, frequently present in duplicate, was seen in direct preparations and short-term cultures of each of ten seminomas, one combined seminoma and teratoma, and one malignant teratoma of the testis. In the four most favorable tumors (seminomas) this chromosome was identified as an i(12p). The findings may point to a chromosomal change that is specific for malignant testicular tumors.

Entities: Disease

Mesh：

Year: 1983 PMID： 6616439 DOI： 10.1016/0165-4608(83)90125-5

Source DB: PubMed Journal: Cancer Genet Cytogenet ISSN： 0165-4608

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Cited

23 in total

1. Restricted 12p amplification and RAS mutation in human germ cell tumors of the adult testis.

Authors: H Roelofs; M C Mostert; K Pompe; G Zafarana; M van Oorschot; R J van Gurp; A J Gillis; H Stoop; B Beverloo; J W Oosterhuis; C Bokemeyer; L H Looijenga
Journal: Am J Pathol Date: 2000-10 Impact factor: 4.307

2. Demonstration of the genuine iso-12p character of the standard marker chromosome of testicular germ cell tumors and identification of further chromosome 12 aberrations by competitive in situ hybridization.

Authors: R F Suijkerbuijk; A Y van de Veen; J van Echten; C H Buys; B de Jong; J W Oosterhuis; D A Warburton; J J Cassiman; D Schonk; A Geurts van Kessel
Journal: Am J Hum Genet Date: 1991-02 Impact factor: 11.025

Review 3. Testicular germ cell tumours: predisposition genes and the male germ cell niche.

Authors: Duncan Gilbert; Elizabeth Rapley; Janet Shipley
Journal: Nat Rev Cancer Date: 2011-03-17 Impact factor: 60.716

4. Correlation of microscopic phenotype with genotype in a formalin-fixed, paraffin-embedded testicular germ cell tumor with universal DNA amplification, comparative genomic hybridization, and interphase cytogenetics.

Authors: M R Speicher; A Jauch; H Walt; S du Manoir; T Ried; W Jochum; T Sulser; T Cremer
Journal: Am J Pathol Date: 1995-06 Impact factor: 4.307

i(12p): specific chromosomal marker in seminoma and malignant teratoma of the testis?

1. Restricted 12p amplification and RAS mutation in human germ cell tumors of the adult testis.

2. Demonstration of the genuine iso-12p character of the standard marker chromosome of testicular germ cell tumors and identification of further chromosome 12 aberrations by competitive in situ hybridization.

Review 3. Testicular germ cell tumours: predisposition genes and the male germ cell niche.

4. Correlation of microscopic phenotype with genotype in a formalin-fixed, paraffin-embedded testicular germ cell tumor with universal DNA amplification, comparative genomic hybridization, and interphase cytogenetics.

5. Germ cell tumour as a diagnostic pitfall of metastatic carcinoma.

Review 6. The stem cell identity of testicular cancer.

7. Loss of heterozygosity in hypotriploid cell cultures from testicular tumours.

8. Correlation between retinoblastoma gene expression and differentiation in human testicular tumors.

Review 9. Small metacentric marker chromosomes, particularly isochromosomes, in cancer.

Review 10. The genomic landscape of testicular germ cell tumours: from susceptibility to treatment.