Literature DB >> 6615830

Amiloride fluxes across erythrocyte membranes.

D J Benos, J Reyes, D G Shoemaker.   

Abstract

Amiloride is known to inhibit both the influx of Na+ and the activation of mitogenesis in many cultured cell lines. This paper describes experiments in which the permeability coefficient of amiloride was determined from measurements of tracer fluxes across human erythrocytes and resealed ghosts. From an analysis of these fluxes, a permeability coefficient of 10(-7) cm/s for the uncharged form of amiloride was deduced. Based upon this measured permeability value, we present calculations of intracellular accumulation times of amiloride in cells of differing surface-to-volume ratio.

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Year:  1983        PMID： 6615830     DOI： 10.1016/0005-2736(83)90080-9

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  10 in total

1.  Basolateral electrogenic Na/HCO3 symport in the amphibian distal tubule.

Authors:  G Planelles; T Anagnostopoulos
Journal:  Pflugers Arch       Date:  1991-02       Impact factor: 3.657

2.  Relationship of octanol/water partition coefficient and molecular weight to cellular permeability and partitioning in s49 lymphoma cells.

Authors:  V A Levin; D Dolginow; H D Landahl; C Yorke; J Csejtey
Journal:  Pharm Res       Date:  1984-11       Impact factor: 4.200

3.  Binding of 3H-phenamil, an irreversible amiloride analog, to toad urinary bladder: effects of aldosterone and vasopressin.

Authors:  J L Garvin; S A Simon; E J Cragoe; L J Mandel
Journal:  J Membr Biol       Date:  1986       Impact factor: 1.843

4.  Cold activation of Na influx through the Na-H exchange pathway in guinea pig red cells.

Authors:  Z Zhao; J S Willis
Journal:  J Membr Biol       Date:  1993-01       Impact factor: 1.843

5.  Millimolar amiloride concentrations block K conductance in proximal tubular cells.

Authors:  F Discala; P Hulin; F Belachgar; G Planelles; A Edelman; T Anagnostopoulos
Journal:  Br J Pharmacol       Date:  1992-10       Impact factor: 8.739

6.  Amiloride blockable sodium fluxes in toad bladder membrane vesicles.

Authors:  H Garty
Journal:  J Membr Biol       Date:  1984       Impact factor: 1.843

Review 7.  Amiloride and its analogs as tools in the study of ion transport.

Authors:  T R Kleyman; E J Cragoe
Journal:  J Membr Biol       Date:  1988-10       Impact factor: 1.843

8.  Effect of sodium on amiloride- and triamterene-induced current fluctuations in isolated frog skin.

Authors:  T Hoshiko; W Van Driessche
Journal:  J Gen Physiol       Date:  1986-03       Impact factor: 4.086

9.  The comprehensive analysis of DEG/ENaC subunits in Hydra reveals a large variety of peptide-gated channels, potentially involved in neuromuscular transmission.

Authors:  Marc Assmann; Anne Kuhn; Stefan Dürrnagel; Thomas W Holstein; Stefan Gründer
Journal:  BMC Biol       Date:  2014-10-14       Impact factor: 7.431

10.  Na/H exchange in cultured chick heart cells. pHi regulation.

Authors:  D Piwnica-Worms; R Jacob; C R Horres; M Lieberman
Journal:  J Gen Physiol       Date:  1985-01       Impact factor: 4.086
  10 in total

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