| Literature DB >> 6615713 |
M Luscombe, J M Poulding, B Amer, J R Clamp, M Hartog, J H Shelley, C R Tribe.
Abstract
Diabetes was induced in male Wistar rats by a single i.v. injection of streptozotocin (40 mg/kg). Animals were treated with bromhexine at 2 dose levels (2.5 mg/kg/day and 25 mg/kg/day) for 13 months thereafter and compared to non-diabetic controls and untreated diabetic animals. Renal pathology showed a significant increase in glomerular volume and basement membrane thickening in untreated diabetic animals. The higher dose bromhexine treated diabetic animals showed a significant decrease in glomerular volume as compared with diabetic animals not given bromhexine.Entities:
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Year: 1983 PMID： 6615713 PMCID： PMC2040793
Source DB: PubMed Journal: Br J Exp Pathol ISSN： 0007-1021