Literature DB >> 6615711

Pathological changes in rats receiving cyclosporin A at immunotherapeutic dosage for 7 weeks.

P H Whiting, J G Simpson, R J Davidson, A W Thomson.   

Abstract

In rats given an immunotherapeutic dose (25 mg/kg orally each day for 7 weeks) of cyclosporin A (Cy A) characteristic drug-induced pathological changes were observed, including impaired liver function, renal proximal tubular cell damage, progressive lymphopenia, lymphocyte depletion in lymphoid organs and marrow hypoplasia. Several additional and previously unreported features of Cy A toxicity were also demonstrated. The changes in renal and hepatic function were biphasic with temporary improvement during the course of the study. The most striking liver damage was in the form of a granulomatous hepatitis and a hypochromic microcytic anaemia developed in all experimental animals.

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Year:  1983        PMID： 6615711      PMCID： PMC2040790     

Source DB:  PubMed          Journal:  Br J Exp Pathol        ISSN： 0007-1021


  17 in total

1.  Mechanism of the anemia of chronic disorders: correlation of heamtocrit value with albumin, vitamin B 12 , transferrin, and iron stores.

Authors:  J E Kurnick; H P Ward; J C Pickett
Journal:  Arch Intern Med       Date:  1972-09

2.  Provocation of infection due to Pneumocystis carinii by cyclosporin A.

Authors:  W T Hughes; B Smith
Journal:  J Infect Dis       Date:  1982-05       Impact factor: 5.226

3.  Anaemia and chronic disease.

Authors:  D P Bentley
Journal:  Clin Haematol       Date:  1982-06

4.  Nature of the toxicity of cyclosporin A in the rat.

Authors:  M J Farthing; M L Clark
Journal:  Biochem Pharmacol       Date:  1981-12-15       Impact factor: 5.858

5.  A toxicological study in rats receiving immunotherapeutic doses of cyclosporin A.

Authors:  A W Thomson; P H Whiting; I D Cameron; S E Lessels; J G Simpson
Journal:  Transplantation       Date:  1981-02       Impact factor: 4.939

6.  Experimental cyclosporin A nephrotoxicity.

Authors:  P H Whiting; A W Thomson; J T Blair; J G Simpson
Journal:  Br J Exp Pathol       Date:  1982-02

7.  Pathological changes developing in the rat during a 3-week course of high dosage cyclosporin A and their reversal following drug withdrawal.

Authors:  A W Thomson; P H Whiting; J T Blair; R J Davidson; J G Simpson
Journal:  Transplantation       Date:  1981-10       Impact factor: 4.939

8.  Cyclosporin A: effects on the mouse thymus.

Authors:  B Ryffel; H Deyssenroth; J F Borel
Journal:  Agents Actions       Date:  1981-07

9.  Serum and urine N-acetyl-beta-D-glucosaminidase in diabetics on diagnosis and subsequent treatment, and stable insulin dependent diabetics.

Authors:  P H Whiting; I S Ross; L Borthwick
Journal:  Clin Chim Acta       Date:  1979-03-15       Impact factor: 3.786

10.  Immune responses to organ allografts. III. Marked decrease in medullary thymocytes and splenic T lymphocytes after cyclosporin A treatment.

Authors:  W M Baldwin; I F Hutchinson; C J Meijer; N L Tilney
Journal:  Transplantation       Date:  1981-02       Impact factor: 4.939
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  6 in total

1.  Renal function in rats treated with cyclosporin following unilateral nephrectomy.

Authors:  P H Whiting; J I Duncan; M P Gavin; S D Heys; J G Simpson; S K Asfar; A W Thomson
Journal:  Br J Exp Pathol       Date:  1985-10

2.  Immunosuppressive activity and toxicity of cyclosporin A in rats pretreated with high dose cyclophosphamide.

Authors:  P A Brown; A W Thomson; P H Whiting; R J Davidson; J G Simpson
Journal:  Agents Actions       Date:  1985-10

3.  Cyclosporin and renal graft histology.

Authors:  A J d'Ardenne; M S Dunnill; J F Thompson; D McWhinnie; R F Wood; P J Morris
Journal:  J Clin Pathol       Date:  1986-02       Impact factor: 3.411

4.  Effect of chronic administration of cyclosporin A on hepatic uptake and biliary secretion of bromosulfophthalein in rat.

Authors:  J F Cadranel; M Dumont; V A Mesa; C Degott; D Touchard; S Erlinger
Journal:  Dig Dis Sci       Date:  1991-02       Impact factor: 3.199

5.  Oxygen radical formation during cytochrome P450-catalyzed cyclosporine metabolism in rat and human liver microsomes at varying hydrogen ion concentrations.

Authors:  S S Ahmed; K L Napoli; H W Strobel
Journal:  Mol Cell Biochem       Date:  1995-10-18       Impact factor: 3.396

Review 6.  Cyclosporine: immunology, toxicity and pharmacology in experimental animals.

Authors:  A W Thomson; P H Whiting; J G Simpson
Journal:  Agents Actions       Date:  1984-10
  6 in total

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