Literature DB >> 6615686

Some tetracycline drugs suppress mitogen-stimulated lymphocyte growth but others do not.

R C Potts, A MacConnachie, R A Brown, J H Gibbs, A J Robertson, H A Hassan, J S Beck.   

Abstract

Eight tetracycline drugs were tested for inhibitory effect on phytohaemagglutinin (PHA) stimulated growth (measured by [3H]-TdR uptake) of peripheral blood mononuclear cells: at least 26 normal subjects were tested with each drug. Doxycycline reduced DNA synthesis appreciably at concentrations within and just above the therapeutic range of blood levels: it was the most potent inhibitor, but demeclocycline, methacycline and minocycline had similar, if less potent, effects. Tetracycline, oxytetracycline, chlortetracycline and clomocycline did not inhibit DNA synthesis of 3-day cultures even at concentrations five to ten times greater than the therapeutic blood level. Volume spectroscopy measurements showed that none of the eight tetracycline drugs interfered with the recruitment of cells into G1-phase growth of the first cell cycle after PHA stimulation.

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Year:  1983        PMID： 6615686      PMCID： PMC1427975          DOI： 10.1111/j.1365-2125.1983.tb04975.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  13 in total

1.  Antibiotics and suppression of lymphocyte function in vitro.

Authors:  G Banck; A Forsgren
Journal:  Antimicrob Agents Chemother       Date:  1979-11       Impact factor: 5.191

2.  Penetration of antimicrobials into tissue culture cells and leucocytes.

Authors:  K N Brown; A Percival
Journal:  Scand J Infect Dis Suppl       Date:  1978

3.  Measurement by Quantimet 720 of the proportion of actively growing cells in tissue cultures of human lymphocytes.

Authors:  R A Brown; R McWalter; W Slidders; J Gibbs; J Swanson Beck
Journal:  J Microsc       Date:  1979-01       Impact factor: 1.758

Review 4.  Inhibition of mammalian protein synthesis by antibiotics.

Authors:  N S Bread; S A Armentrout; A S Weisberger
Journal:  Pharmacol Rev       Date:  1969-09       Impact factor: 25.468

5.  A new method of testing for mitogen-induced lymphocyte stimulation: measurement of the percentage of growing cells and of some aspects of their cell kinetics with an electronic particle counter.

Authors:  J H Gibbs; R A Brown; A J Robertson; R C Potts; J S Beck
Journal:  J Immunol Methods       Date:  1979       Impact factor: 2.303

6.  A simple method for determining the extent of cellular contamination in peripheral blood lymphocyte preparations.

Authors:  R C Potts; J H Gibbs; A J Robertson; R A Brown; J S Beck
Journal:  J Immunol Methods       Date:  1980       Impact factor: 2.303

7.  pH-Partition behavior of tetracyclines.

Authors:  J L Colaizzi; P R Klink
Journal:  J Pharm Sci       Date:  1969-10       Impact factor: 3.534

8.  Influence of repetitive dosing of tetracyclines on biologic half-life in serum.

Authors:  J T Doluisio; L W Dittert
Journal:  Clin Pharmacol Ther       Date:  1969 Sep-Oct       Impact factor: 6.875

9.  Inhibition of mitogen-induced human lymphocyte proliferative responses by tetracycline analogues.

Authors:  Y H Thong; A Ferrante
Journal:  Clin Exp Immunol       Date:  1979-03       Impact factor: 4.330

10.  Serum inhibitory factor in lepromatous leprosy: its effect on the pre-S-phase cell-cycle kinetics of mitogen-stimulated normal human lymphocytes.

Authors:  R C Potts; M M Sherif; A J Robertson; J H Gibbs; R A Brown; J S Beck
Journal:  Scand J Immunol       Date:  1981-09       Impact factor: 3.487
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  5 in total

1.  Protracted systemic illness and interstitial nephritis due to minocycline.

Authors:  S P Wilkinson; W K Stewart; E M Spiers; J Pears
Journal:  Postgrad Med J       Date:  1989-01       Impact factor: 2.401

2.  Changes in activation markers and cell membrane receptors on human peripheral blood T lymphocytes during cell cycle progression after PHA stimulation.

Authors:  T A Poulton; A Gallagher; R C Potts; J S Beck
Journal:  Immunology       Date:  1988-07       Impact factor: 7.397

3.  In vitro effects of doxycycline and tetracycline on mitogen stimulated lymphocyte growth.

Authors:  R C Potts; H A Hassan; R A Brown; A MacConnachie; J H Gibbs; A J Robertson; J S Beck
Journal:  Clin Exp Immunol       Date:  1983-08       Impact factor: 4.330

4.  Mechanical phenotyping of K562 cells by the Micropipette Aspiration Technique allows identifying mechanical changes induced by drugs.

Authors:  Alessandro Di Cerbo; Valentina Rubino; Francesca Morelli; Giuseppina Ruggiero; Rosaria Landi; Gianandrea Guidetti; Sergio Canello; Giuseppe Terrazzano; Andrea Alessandrini
Journal:  Sci Rep       Date:  2018-01-19       Impact factor: 4.379

5.  Oxytetracycline induces DNA damage and epigenetic changes: a possible risk for human and animal health?

Authors:  Adriana Gallo; Rosaria Landi; Valentina Rubino; Alessandro Di Cerbo; Angela Giovazzino; Anna Teresa Palatucci; Sara Centenaro; Gianandrea Guidetti; Sergio Canello; Laura Cortese; Giuseppina Ruggiero; Andrea Alessandrini; Giuseppe Terrazzano
Journal:  PeerJ       Date:  2017-04-27       Impact factor: 2.984
  5 in total

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