Reduced oxygen enhancement of the radiosensitivity of glutathione-deficient fibroblasts.

Following the demonstration of the radioprotective role of artificial aminothiols, the question logically arose concerning the role of aminothiols present naturally in cells: non-protein bound sulfhydryls (NPSH), especially glutathione (GSH). The latter is the most abundant NPSH and would be a likely candidate for a radioprotector.