Literature DB >> 6611521

Antibody to acetylcholine receptor in myasthenia gravis: production by lymphocytes from thymus or thymoma.

Y Fujii, Y Monden, K Nakahara, J Hashimoto, Y Kawashima.   

Abstract

In 13 of 17 myasthenic patients without thymoma and all 7 patients with thymoma, thymic lymphocytes produced antibody to acetylcholine receptor (AChR). Lymphocytes from the thymoma itself did not produce AChR antibody except in one patient. The rate of antibody production was higher in patients without thymoma than in patients with thymoma (32.5 and 3.9 fmol/10(6) cells/week, respectively). The rate of antibody production was related to the serum titer of AChR antibody (r = 0.7, p less than 0.001). Enrichment of B cells using a nylon wool column increased the rate of antibody production by thymic lymphocytes 1.3- to 8.0-fold.

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Year:  1984        PMID： 6611521     DOI： 10.1212/wnl.34.9.1182

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  13 in total

1.  Thymus cells in myasthenia gravis: a two-colour flow cytometric analysis of lymphocytes in the thymus and thymoma.

Authors:  Y Fujii; M Hayakawa; K Nakahara
Journal:  J Neurol       Date:  1992-02       Impact factor: 4.849

2.  Antibodies to acetylcholine receptors in myasthenia gravis. In vitro synthesis by peripheral blood lymphocytes before and after thymectomy.

Authors:  J B Kuks; P C Limburg; H J Oosterhuis; T H The
Journal:  Clin Exp Immunol       Date:  1992-02       Impact factor: 4.330

3.  Circulating CD4+CD8+ cells in myasthenia gravis: supplementary immunological parameter for long-term prognosis.

Authors:  M Matsui; H Fukuyama; I Akiguchi; M Kameyama
Journal:  J Neurol       Date:  1989-09       Impact factor: 4.849

4.  A pathogenetic role for the thymoma in myasthenia gravis. Autosensitization of IL-4- producing T cell clones recognizing extracellular acetylcholine receptor epitopes presented by minority class II isotypes.

Authors:  N Nagvekar; A M Moody; P Moss; I Roxanis; J Curnow; D Beeson; N Pantic; J Newsom-Davis; A Vincent; N Willcox
Journal:  J Clin Invest       Date:  1998-05-15       Impact factor: 14.808

5.  Steroid therapy without primary dose escalation for postthymectomy crisis in 2 thymomatous myasthenia gravis patients.

Authors:  Masayoshi Inoue; Kentaro Kimura; Katsuko Hasegawa; Kiyohiro Fujiwara; Katsuhiro Nakagawa; Tsutomu Yasumitsu
Journal:  Jpn J Thorac Cardiovasc Surg       Date:  2002-04

6.  T helper cell recognition of muscle acetylcholine receptor in myasthenia gravis. Epitopes on the gamma and delta subunits.

Authors:  A A Manfredi; M P Protti; M W Dalton; J F Howard; B M Conti-Tronconi
Journal:  J Clin Invest       Date:  1993-08       Impact factor: 14.808

7.  Myasthenia gravis induces the activation and maturation of lymphocytes in thymoma.

Authors:  K Takahashi; Y Monden; S Saito; Y Kamamura; T Uyama
Journal:  J Clin Immunol       Date:  1996-07       Impact factor: 8.317

8.  In vitro anti-acetylcholine receptor antibody synthesis by myasthenia gravis patient lymphocytes: correlations with thymic histology and thymic epithelial-cell interactions.

Authors:  D Safar; S Berrih-Aknin; E Morel
Journal:  J Clin Immunol       Date:  1987-05       Impact factor: 8.317

Review 9.  Paraneoplastic syndromes of the nervous system.

Authors:  G Palma
Journal:  West J Med       Date:  1985-06

Review 10.  Thymus, thymoma and myasthenia gravis.

Authors:  Yoshitaka Fujii
Journal:  Surg Today       Date:  2012-09-05       Impact factor: 2.549
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