Literature DB >> 6611297

Functional properties of lymphocytes isolated from murine small intestinal epithelium.

S B Dillon, T T MacDonald.   

Abstract

Intraepithelial lymphocytes (IEL) were isolated from murine small intestine using a modification of previously published procedures. Analysis of IEL by immunofluorescence using monoclonal antibodies showed they were predominantly Lyt-2+ cells, with relatively few B cells or macrophages present. IEL cultured at sufficiently high cell densities proliferated in response to concanavalin A (Con A), phytohaemagglutin (PHA) and lipopolysaccharide (LPS). IEL were also capable of recognizing alloantigens in an in vivo graft-versus-host assay and in an in vitro mixed lymphocyte reaction. These studies therefore confirm that murine IEL contain cells with immunologic properties characteristic of typical T lymphocytes.

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Year:  1984        PMID： 6611297      PMCID： PMC1454501     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  20 in total

1.  Biological expressions of lymphocyte activation. V. Characterization of a soluble immune response suppressor (SIRS) produced by concanavalin A-activated spleen cells.

Authors:  T Tadakuma; A L Kühner; R R Rich; J R David; C W Pierce
Journal:  J Immunol       Date:  1976-07       Impact factor: 5.422

Review 2.  Intraepithelial lymphocytes of the small intestine.

Authors:  A Ferguson
Journal:  Gut       Date:  1977-11       Impact factor: 23.059

3.  Immunohistochemical observations on lymphoid tissues from conventional and germ-free mice.

Authors:  P A Crabbé; D R Nash; H Bazin; H Eyssen; J F Heremans
Journal:  Lab Invest       Date:  1970-05       Impact factor: 5.662

4.  Mac-1: a macrophage differentiation antigen identified by monoclonal antibody.

Authors:  T Springer; G Galfré; D S Secher; C Milstein
Journal:  Eur J Immunol       Date:  1979-04       Impact factor: 5.532

5.  In vitro characterization of human intestinal intraepithelial lymphocytes.

Authors:  J H Greenwood; L L Austin; W O Dobbins
Journal:  Gastroenterology       Date:  1983-11       Impact factor: 22.682

6.  T lymphocyte subsets in human intestinal mucosa: the distribution and relationship to MHC-derived antigens.

Authors:  W S Selby; G Janossy; G Goldstein; D P Jewell
Journal:  Clin Exp Immunol       Date:  1981-06       Impact factor: 4.330

7.  Kinetics of intraepithelial lymphocytes in the small intestine of thymus-deprived mice and antigen-deprived mice.

Authors:  C Röpke; N B Everett
Journal:  Anat Rec       Date:  1976-05

8.  Preparation and purification of lymphocytes from the epithelium and lamina propria of murine small intestine.

Authors:  M D Davies; D M Parrott
Journal:  Gut       Date:  1981-06       Impact factor: 23.059

9.  Cytotoxic activities of gut mucosal lymphoid cells in guinea pigs.

Authors:  F Arnaud-Battandier; B M Bundy; M O'Neill; J Bienenstock; D L Nelson
Journal:  J Immunol       Date:  1978-09       Impact factor: 5.422

10.  The mouse gut T lymphocyte, a novel type of T cell. Nature, origin, and traffic in mice in normal and graft-versus-host conditions.

Authors:  D Guy-Grand; C Griscelli; P Vassalli
Journal:  J Exp Med       Date:  1978-12-01       Impact factor: 14.307
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  28 in total

1.  Functional characterization of Con A-responsive Lyt2-positive mouse small intestinal intraepithelial lymphocytes.

Authors:  S B Dillon; T T MacDonald
Journal:  Immunology       Date:  1986-11       Impact factor: 7.397

2.  Villous B cells of the small intestine are specialized for invariant NK T cell dependence.

Authors:  Peter Velázquez; Bo Wei; Michael McPherson; Lesley Marie A Mendoza; Sandra L Nguyen; Olga Turovskaya; Mitchell Kronenberg; Tiffany T Huang; Matthew Schrage; Lynn N Lobato; Daisuke Fujiwara; Sarah Brewer; Moshe Arditi; Genhong Cheng; R Balfour Sartor; Rodney D Newberry; Jonathan Braun
Journal:  J Immunol       Date:  2008-04-01       Impact factor: 5.422

3.  Morphology and functional characteristics of isolated porcine intraepithelial lymphocytes.

Authors:  A D Wilson; C R Stokes; F J Bourne
Journal:  Immunology       Date:  1986-09       Impact factor: 7.397

4.  Antigen presentation by epithelial cells of the rat small intestine. II. Selective induction of suppressor T cells.

Authors:  P W Bland; L G Warren
Journal:  Immunology       Date:  1986-05       Impact factor: 7.397

5.  Activation of lymphocytes isolated from the gastric mucosa of the mouse.

Authors:  H J Andress; L Brent
Journal:  Immunology       Date:  1987-12       Impact factor: 7.397

6.  Isolation and functional characterization of chicken intestinal intra-epithelial lymphocytes showing natural killer cell activity against tumour target cells.

Authors:  J Y Chai; H S Lillehoj
Journal:  Immunology       Date:  1988-01       Impact factor: 7.397

7.  Functional characteristics of intraepithelial lymphocytes from mouse small intestine. III. Inability of intraepithelial lymphocytes to induce a systemic graft-versus-host reaction is because of failure to migrate in vivo.

Authors:  M E Baca; A M Mowat; S MacKenzie; D M Parrott
Journal:  Gut       Date:  1987-10       Impact factor: 23.059

8.  Functional characteristics of intraepithelial lymphocytes from mouse small intestine. II. In vivo and in vitro responses of intraepithelial lymphocytes to mitogenic and allogeneic stimuli.

Authors:  A M Mowat; S MacKenzie; M E Baca; M V Felstein; D M Parrott
Journal:  Immunology       Date:  1986-08       Impact factor: 7.397

9.  Lymphokine secretion and proliferation of intraepithelial lymphocytes from murine small intestine.

Authors:  J L Viney; T T MacDonald
Journal:  Immunology       Date:  1992-09       Impact factor: 7.397

10.  Frequency of occurrence and distribution of the intra-epithelial lymphoid cells in the follicle-associated epithelium in phenotypically normal and athymic nude mice.

Authors:  K W Rell; J Lamprecht; P Siciński; W Bem; J Rowiński
Journal:  J Anat       Date:  1987-06       Impact factor: 2.610
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