Literature DB >> 6611151

Secretagogue-induced formation of inositol phosphates in rat exocrine pancreas. Implications for a messenger role for inositol trisphosphate.

R P Rubin, P P Godfrey, D A Chapman, J W Putney.   

Abstract

The formation of inositol phosphates in response to secretagogues was studied in rat pancreatic acini preincubated with [3H]inositol. Carbachol caused rapid increases in radioactive inositol phosphate, inositol bisphosphate and inositol trisphosphate . This effect was blocked by atropine, and also elicited by caerulein, but not by ionomycin or phorbol dibutyrate. Thus phospholipase C-mediated breakdown of polyphosphoinositides, with the resulting formation of inositol phosphates, may be an early step in the stimulus-secretion coupling pathway in exocrine pancreas. Inositol trisphosphate may function as a second messenger in the exocrine pancreas, coupling receptor activation to internal Ca2+ release.

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Year:  1984        PMID： 6611151      PMCID： PMC1153524          DOI： 10.1042/bj2190655

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  17 in total

Review 1.  Inositol phospholipids and cell surface receptor function.

Authors:  R H Michell
Journal:  Biochim Biophys Acta       Date:  1975-03-25

Review 2.  Dynamic aspects of phospholipids during protein secretion.

Authors:  L E Hokin
Journal:  Int Rev Cytol       Date:  1968

3.  Ca2+-dependent and Ca2+-independent effects of pancreatic secretagogues on phosphatidylinositol metabolism.

Authors:  R V Farese; R E Larson; M A Sabir
Journal:  Biochim Biophys Acta       Date:  1982-03-12

4.  Stimulation by vasopressin and alpha-catecholamines of phosphatidylinositol formation in isolated rat liver parenchymal cells.

Authors:  M E Tolbert; A C White; K Aspry; J Cutts; J N Fain
Journal:  J Biol Chem       Date:  1980-03-10       Impact factor: 5.157

5.  Kinetics of amylase release by dispersed acini prepared from guinea pig pancreas.

Authors:  S R Peikin; A J Rottman; S Batzri; J D Gardner
Journal:  Am J Physiol       Date:  1978-12

6.  Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

Authors:  M Castagna; Y Takai; K Kaibuchi; K Sano; U Kikkawa; Y Nishizuka
Journal:  J Biol Chem       Date:  1982-07-10       Impact factor: 5.157

7.  Cation transport and specificity of ionomycin. Comparison with ionophore A23187 in rat liver mitochondria.

Authors:  R F Kauffman; R W Taylor; D R Pfeiffer
Journal:  J Biol Chem       Date:  1980-04-10       Impact factor: 5.157

8.  Pancreatic acinar cell function: measurement of intracellular ions and pH and their relation to secretion.

Authors:  M Preissler; J A Williams
Journal:  J Physiol       Date:  1981-12       Impact factor: 5.182

9.  Evidence for a role in stimulus--secretion coupling of prostaglandins derived from release of arachidonoyl residues as a result of phosphatidylinositol breakdown.

Authors:  P J Marshall; J F Dixon; L E Hokin
Journal:  Proc Natl Acad Sci U S A       Date:  1980-06       Impact factor: 11.205

10.  Effect of atropine, ouabain, antimycin A, and A23187 on "trigger Ca2+ pool" in exocrine pancreas.

Authors:  H Stolze; I Schulz
Journal:  Am J Physiol       Date:  1980-04
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  14 in total

Review 1.  The role of phosphoinositides in signal transduction.

Authors:  M C Sekar; L E Hokin
Journal:  J Membr Biol       Date:  1986       Impact factor: 1.843

2.  Antigen-stimulated metabolism of inositol phospholipids in the cloned murine mast-cell line MC9.

Authors:  M W Musch; M I Siegel
Journal:  Biochem J       Date:  1986-02-15       Impact factor: 3.857

3.  Diminished agonist-stimulated inositol trisphosphate generation blocks stimulus-secretion coupling in mouse pancreatic acini during diet-induced experimental pancreatitis.

Authors:  R E Powers; A K Saluja; M J Houlihan; M L Steer
Journal:  J Clin Invest       Date:  1986-05       Impact factor: 14.808

4.  Caerulein and carbamoylcholine stimulate pancreatic amylase release at resting cytosolic free Ca2+.

Authors:  R Bruzzone; T Pozzan; C B Wollheim
Journal:  Biochem J       Date:  1986-04-01       Impact factor: 3.857

5.  Involvement of phosphoinositide metabolism in potentiation by adrenaline of ADP-induced aggregation of rabbit platelets.

Authors:  C Lalau Keraly; J D Vickers; R L Kinlough-Rathbone; J F Mustard
Journal:  Biochem J       Date:  1987-03-15       Impact factor: 3.857

6.  Secretin induces rapid increases in inositol trisphosphate, cytosolic Ca2+ and diacylglycerol as well as cyclic AMP in rat pancreatic acini.

Authors:  E R Trimble; R Bruzzone; T J Biden; R V Farese
Journal:  Biochem J       Date:  1986-10-15       Impact factor: 3.857

7.  The decrease in phosphatidylinositol 4,5-bisphosphate in ADP-stimulated washed rabbit platelets is not primarily due to phospholipase C activation.

Authors:  J D Vickers; R L Kinlough-Rathbone; J F Mustard
Journal:  Biochem J       Date:  1986-07-15       Impact factor: 3.857

8.  Gonadotropin releasing hormone stimulates the formation of inositol phosphates in rat anterior pituitary tissue.

Authors:  M P Schrey
Journal:  Biochem J       Date:  1985-03-01       Impact factor: 3.857

9.  Muscarinic-receptor activation stimulates oscillations in K+ and Cl- currents which are acutely dependent on extracellular Ca2+ in avian salt gland cells.

Authors:  S C Martin; T J Shuttleworth
Journal:  Pflugers Arch       Date:  1994-02       Impact factor: 3.657

10.  Pancreatic amylase secretion and cytoplasmic free calcium. Effects of ionomycin, phorbol dibutyrate and diacylglycerols alone and in combination.

Authors:  J E Merritt; R P Rubin
Journal:  Biochem J       Date:  1985-08-15       Impact factor: 3.857
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