Literature DB >> 6610386

Subinhibitory concentrations of imipenem induce increased resistance to methicillin and imipenem in vitro in methicillin-resistant Staphylococcus aureus.

B A Forbes, K D McClatchey, D R Schaberg.   

Abstract

Methicillin-resistant (MR) Staphylococcus aureus that was susceptible to less than 0.75 micrograms of imipenem per ml demonstrated inducible resistance. MR S. aureus preincubated with 0.05 microgram of imipenem per ml grew in medium with an imipenem concentration of 32 micrograms/ml, and methicillin MICs increased 20-fold. Non-MR S. aureus exhibited no induction. Preincubation with methicillin produced no effect. Induction appeared to be a unique interaction of imipenem with MR S. aureus.

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Year:  1984        PMID： 6610386      PMCID： PMC185559          DOI： 10.1128/AAC.25.4.491

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

1.  Clinical, epidemiologic and bacteriologic observations of an outbreak of methicillin-resistant Staphylococcus aureus at a large community hospital.

Authors:  J J Klimek; F J Marsik; R C Bartlett; B Weir; P Shea; R Quintiliani
Journal:  Am J Med       Date:  1976-09       Impact factor: 4.965

2.  Suppression of intrinsic resistance to methicillin and other penicillins in Staphylococcus aureus.

Authors:  L D Sabath; S J Wallace; D A Gerstein
Journal:  Antimicrob Agents Chemother       Date:  1972-11       Impact factor: 5.191

3.  Penicillinase production and intrinsic resistance to penicillins in methicillin-resistant cultures of Staphylococcus aureus.

Authors:  K G Dyke
Journal:  J Med Microbiol       Date:  1969-08       Impact factor: 2.472

4.  The effect of temperature on resistance of Staphylococcus aureus to methicillin and some other antibioics.

Authors:  D I Annear
Journal:  Med J Aust       Date:  1968-03-16       Impact factor: 7.738

5.  In-vitro activity of Sch 29482, MK 0787, ceftriaxone and seven other antimicrobials against 840 separate clinical isolates.

Authors:  C L Pierson; D R Schaberg; F R Fekety; K D McClatchey
Journal:  J Antimicrob Chemother       Date:  1982-02       Impact factor: 5.790

6.  Use of a heavy inoculum in the in vitro evaluation of the anti-staphylococcal activity of 19 cephalosporins.

Authors:  M Laverdiere; D Welter; L D Sabath
Journal:  Antimicrob Agents Chemother       Date:  1978-04       Impact factor: 5.191

7.  Epidemiologic studies of an outbreak of nosocomial methicillin-resistant Staphylococcus aureus infections.

Authors:  J M Boyce; M Landry; T R Deetz; H L DuPont
Journal:  Infect Control       Date:  1981 Mar-Apr

8.  Thienamycin, a new beta-lactam antibiotic. I. Discovery, taxonomy, isolation and physical properties.

Authors:  J S Kahan; F M Kahan; R Goegelman; S A Currie; M Jackson; E O Stapley; T W Miller; A K Miller; D Hendlin; S Mochales; S Hernandez; H B Woodruff; J Birnbaum
Journal:  J Antibiot (Tokyo)       Date:  1979-01       Impact factor: 2.649

9.  Antibacterial activities of a new stabilized thienamycin, N-formimidoyl thienamycin, in comparison with other antibiotics.

Authors:  T Kesado; T Hashizume; Y Asahi
Journal:  Antimicrob Agents Chemother       Date:  1980-06       Impact factor: 5.191

10.  Reliability of the Kirby-Bauer disc diffusion method for detecting methicillin-resistant strains of Staphylococcus aureus.

Authors:  W L Drew; A L Barry; R O'Toole; J C Sherris
Journal:  Appl Microbiol       Date:  1972-08
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  6 in total

1.  Role of beta-lactamase and different testing conditions in oxacillin-borderline-susceptible staphylococci.

Authors:  J G Sierra-Madero; C Knapp; C Karaffa; J A Washington
Journal:  Antimicrob Agents Chemother       Date:  1988-12       Impact factor: 5.191

2.  The significance of methicillin-resistant Staphylococcus aureus infection in general surgery: a multivariate analysis of risk factors and preventive approaches.

Authors:  M Shimada; T Kamakura; H Itasaka; T Matsumata; M Hashizume; K Sugimachi
Journal:  Surg Today       Date:  1993       Impact factor: 2.549

Review 3.  In vitro activity of imipenem--a review.

Authors:  I Braveny
Journal:  Eur J Clin Microbiol       Date:  1984-10       Impact factor: 3.267

Review 4.  Imipenem/cilastatin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic efficacy.

Authors:  S P Clissold; P A Todd; D M Campoli-Richards
Journal:  Drugs       Date:  1987-03       Impact factor: 9.546

5.  Emergence of homogeneously methicillin-resistant Staphylococcus aureus.

Authors:  J Fung-Tomc; E Huczko; E Gradelski; K Denbleyker; D P Bonner; R E Kessler
Journal:  J Clin Microbiol       Date:  1991-12       Impact factor: 5.948

6.  Imipenem therapy of experimental Staphylococcus epidermidis endocarditis.

Authors:  A J Berry; J L Johnston; G L Archer
Journal:  Antimicrob Agents Chemother       Date:  1986-05       Impact factor: 5.191
  6 in total

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