Literature DB >> 6609897

Chromosome aberrations in human lymphocytes induced by fission neutrons.

M Bauchinger, L Koester, E Schmid, J Dresp, S Streng.   

Abstract

The dose-response relationships of dicentrics and excess acentrics were analysed after exposure of human lymphocytes to a mixed fission neutron-gamma-ray beam. From the analysis of exclusively first division cells a linear-quadratic relation was obtained for dicentrics with the ratio of linear and quadratic components, zeta, equal to 2.76 Gy. Over the range of doses studied (0.04-1.97 Gy) intratrack events therefore predominated. This also applied to acentrics which were linearly related to dose. At the lowest level of observed effect and dose, r.b.e. values with respect to 60Co gamma-rays of up to about 11 were derived for dicentrics and acentrics. With increasing neutron dose the r.b.e. decreased.

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Year:  1984        PMID： 6609897     DOI： 10.1080/09553008414550651

Source DB:  PubMed          Journal:  Int J Radiat Biol Relat Stud Phys Chem Med        ISSN： 0020-7616


  6 in total

1.  RBE of nearly monoenergetic neutrons at energies of 36 keV-14.6 MeV for induction of dicentrics in human lymphocytes.

Authors:  E Schmid; D Schlegel; S Guldbakke; R-P Kapsch; D Regulla
Journal:  Radiat Environ Biophys       Date:  2003-07-03       Impact factor: 1.925

2.  Cell survival and radiation induced chromosome aberrations. I. Derivation of formulae for the determination of transmission and survival parameters of aberrations.

Authors:  H Braselmann; M Bauchinger; E Schmid
Journal:  Radiat Environ Biophys       Date:  1986       Impact factor: 1.925

3.  Dose-response relationship of dicentric chromosomes in human lymphocytes obtained for the fission neutron therapy facility MEDAPP at the research reactor FRM II.

Authors:  E Schmid; F M Wagner; H Romm; L Walsh; H Roos
Journal:  Radiat Environ Biophys       Date:  2008-11-01       Impact factor: 1.925

4.  Comparison between two FISH techniques in the in vitro study of cytogenetic markers for low-dose X-ray exposure in human primary fibroblasts.

Authors:  D Nieri; F Berardinelli; A Antoccia; C Tanzarella; Antonella Sgura
Journal:  Front Genet       Date:  2013-07-29       Impact factor: 4.599

5.  Relative biological effects of neutron mixed-beam irradiation for boron neutron capture therapy on cell survival and DNA double-strand breaks in cultured mammalian cells.

Authors:  Kakuji Okumura; Yuko Kinashi; Yoshihisa Kubota; Erika Kitajima; Ryuichi Okayasu; Koji Ono; Sentaro Takahashi
Journal:  J Radiat Res       Date:  2012-09-10       Impact factor: 2.724

Review 6.  Neutron relative biological effectiveness in Hiroshima and Nagasaki atomic bomb survivors: a critical review.

Authors:  Masao S Sasaki; Satoru Endo; Masaharu Hoshi; Taisei Nomura
Journal:  J Radiat Res       Date:  2016-09-10       Impact factor: 2.724
  6 in total

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