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Literature DB >> 6609364

Charge movement in skeletal muscle fibers paralyzed by the calcium-entry blocker D600.

Abstract

We report measurements of nonlinear charge movement in frog skeletal muscle fibers paralyzed by the calcium-entry blocker [Schwartz, A. & Taira, N., eds. (1983) Circ. Res. 52, Part II, Number 2, 1-181.] D600 (methoxyverapamil, recently renamed gallopamil). Nonlinear charge movement was not seen in such fibers, suggesting that the drug severs the link between membrane depolarization and the main components of charge movement. This is the only pharmacological agent that blocks the main components of charge movement.

Entities: Chemical Disease

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Year: 1984 PMID： 6609364 PMCID： PMC345107 DOI： 10.1073/pnas.81.8.2582

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

26 in total

7. Increases in intracellular calcium ion concentration during depolarization of cultured embryonic Xenopus spinal neurones.

Authors: M E Barish
Journal: J Physiol Date: 1991-12 Impact factor: 5.182

8. The effect of the phenylalkylamine D888 (devapamil) on force and Ca2+ current in isolated frog skeletal muscle fibres.

Authors: R Erdmann; H C Lüttgau
Journal: J Physiol Date: 1989-06 Impact factor: 5.182

9. The effect of D600 on potassium contractures of slow muscle fibres of Rana temporaria.

Authors: H Schmidt; M Siebler; P Krippeit-Drews
Journal: Pflugers Arch Date: 1988-09 Impact factor: 3.657

10. Components of charge movement in rabbit skeletal muscle: the effect of tetracaine and nifedipine.

Authors: G D Lamb
Journal: J Physiol Date: 1986-07 Impact factor: 5.182

Charge movement in skeletal muscle fibers paralyzed by the calcium-entry blocker D600.

1. A non-linear voltage dependent charge movement in frog skeletal muscle.

Review 2. Gating currents and charge movements in excitable membranes.

3. Charge movement and membrane capacity in frog muscle.

4. Voltage dependent charge movement of skeletal muscle: a possible step in excitation-contraction coupling.

5. Twitches in the presence of ethylene glycol bis( -aminoethyl ether)-N,N'-tetracetic acid.

6. Regenerative calcium release within muscle cells.

7. Electrical models of excitation-contraction coupling and charge movement in skeletal muscle.

8. Effects of glycerol treatment and maintained depolarization on charge movement in skeletal muscle.

9. Voltage clamp experiments in striated muscle fibres.

10. Charge movement associated with the opening and closing of the activation gates of the Na channels.

Review 1. DHP receptors and excitation-contraction coupling.

2. Effects of gallopamil on calcium release and intramembrane charge movements in frog skeletal muscle fibres.

3. D600 binding sites on voltage-sensors for excitation-contraction coupling in frog skeletal muscle are intracellular.

4. Fast gating kinetics of the slow Ca2+ current in cut skeletal muscle fibres of the frog.

5. Contractile properties of frog twitch fibres after D600 paralysis.

Review 6. Does muscle activation occur by direct mechanical coupling of transverse tubules to sarcoplasmic reticulum?

7. Increases in intracellular calcium ion concentration during depolarization of cultured embryonic Xenopus spinal neurones.

8. The effect of the phenylalkylamine D888 (devapamil) on force and Ca2+ current in isolated frog skeletal muscle fibres.

9. The effect of D600 on potassium contractures of slow muscle fibres of Rana temporaria.

10. Components of charge movement in rabbit skeletal muscle: the effect of tetracaine and nifedipine.