| Literature DB >> 6609282 |
S M Neudorf, T W LeBien, J H Kersey.
Abstract
We studied the relationship between CALLA + thymocytes and two known markers of T-lymphocyte differentiation, Tdt and the sheep erythrocyte receptor. Thymocytes were studied using double fluorochrome analysis (with monoclonal anti-CALLA antibody and anti-Tdt) before and after E rosette separation. We found that approx. 4% of unseparated thymocytes were CALLA + and that most CALLA + cells were also Tdt +. After E rosettes separation CALLA + Tdt + cells were found mostly in the ER- fraction (20% of ER- cells) while only 1.0% of ER + cells were CALLA +. The expression of CALLA on ER- Tdt + thymocytes suggests that CALLA may define cells early in T-cell differentiation.Entities:
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Year: 1984 PMID: 6609282 DOI: 10.1016/0145-2126(84)90140-1
Source DB: PubMed Journal: Leuk Res ISSN: 0145-2126 Impact factor: 3.156