Literature DB >> 6608345

Immunologic analysis of intraocular mononuclear cell infiltrates in uveitis.

H J Kaplan, J C Waldrep, J K Nicholson, D Gordon.   

Abstract

The pathogenesis of chronic idiopathic uveitis is not known. Analysis of inflammatory site (ie, intraocular) lymphocytes in the aqueous humor and/or vitreous cavity was performed with monoclonal antibodies and a cell sorter. The mononuclear cell population within the aqueous humor of eyes with acute idiopathic uveitis resembled that observed in the peripheral blood. In contrast, eyes with chronic idiopathic uveitis displayed a scarcity of T cells within the vitreous. Eyes with chronic uveitis of presumed infectious cause did not show similar changes. These observations are consistent with the hypothesis that intraocular T-cell immunoregulation of B-cell function may be defective in some stages of chronic idiopathic uveitis.

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Year:  1984        PMID： 6608345     DOI： 10.1001/archopht.1984.01040030450024

Source DB:  PubMed          Journal:  Arch Ophthalmol        ISSN： 0003-9950


  5 in total

1.  Activated T lymphocytes in uveitis.

Authors:  J Deschênes; D H Char; S Kaleta
Journal:  Br J Ophthalmol       Date:  1988-02       Impact factor: 4.638

2.  The number of CD8+ T cells and NKT cells increases in the aqueous humor of patients with Behçet's uveitis.

Authors:  H G Yu; D S Lee; J M Seo; J K Ahn; Y S Yu; W J Lee; H Chung
Journal:  Clin Exp Immunol       Date:  2004-08       Impact factor: 4.330

3.  Analysis of aqueous humour in uveitis by high performance liquid chromatography and sodium dodecyl sulphate-polyacrylamide gel electrophoresis.

Authors:  P I Murray; R Hoekzema; L Luyendijk; A Kijlstra
Journal:  Int Ophthalmol       Date:  1992-01       Impact factor: 2.031

4.  Identifying RNA Biomarkers and Molecular Pathways Involved in Multiple Subtypes of Uveitis.

Authors:  James T Rosenbaum; Christina A Harrington; Robert P Searles; Suzanne S Fei; Amr Zaki; Sruthi Arepalli; Michael A Paley; Lynn M Hassman; Albert T Vitale; Christopher D Conrady; Puthyda Keath; Claire Mitchell; Lindsey Watson; Stephen R Planck; Tammy M Martin; Dongseok Choi
Journal:  Am J Ophthalmol       Date:  2021-01-24       Impact factor: 5.488

Review 5.  Involvement of B cells in non-infectious uveitis.

Authors:  Justine R Smith; Andrew J Stempel; Arpita Bharadwaj; Binoy Appukuttan
Journal:  Clin Transl Immunology       Date:  2016-02-05
  5 in total

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