Literature DB >> 6607735

Clonal heterogeneity in the fibroblast response to mononuclear cell derived mediators.

J H Korn, D Torres, E Downie.   

Abstract

Human dermal fibroblasts were examined for heterogeneity in proliferation and prostaglandin E2 (PGE2) synthetic response to supernates of mitogen activated mononuclear cell cultures. Eleven substrains from a single neonatal foreskin culture displayed marked clonal heterogeneity in the fibroblast response to mononuclear cell derived mediators. Supernates of mononuclear cell cultures stimulated fibroblast PGE2 synthesis and suppressed proliferation. Substrains displayed tenfold differences in PGE synthesis and the extent of growth suppression. Release of immunologic mediators at sites of inflammatory lesions could lead to alterations in the clonal composition and phenotypic expression of connective tissue cells.

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Year:  1984        PMID： 6607735     DOI： 10.1002/art.1780270208

Source DB:  PubMed          Journal:  Arthritis Rheum        ISSN： 0004-3591


  11 in total

Review 1.  Interactions of fibroblasts with the extracellular matrix: implications for the understanding of fibrosis.

Authors:  B Eckes; D Kessler; M Aumailley; T Krieg
Journal:  Springer Semin Immunopathol       Date:  1999

2.  Collagen turnover is diminished by different clones of skin fibroblasts from early- but not late-stage systemic sclerosis.

Authors:  Camilo S Zurita-Salinas; Edgar Krötzsch; Lino Díaz de León; Jorge Alcocer-Varela
Journal:  Rheumatol Int       Date:  2003-11-05       Impact factor: 2.631

3.  Leukoregulin induction of protein expression in human orbital fibroblasts: evidence for anatomical site-restricted cytokine-target cell interactions.

Authors:  D A Young; C H Evans; T J Smith
Journal:  Proc Natl Acad Sci U S A       Date:  1998-07-21       Impact factor: 11.205

4.  Heterogeneity in hormone responses and patterns of collagen synthesis in cloned dermal fibroblasts.

Authors:  S R Goldring; M L Stephenson; E Downie; S M Krane; J H Korn
Journal:  J Clin Invest       Date:  1990-03       Impact factor: 14.808

5.  Discrimination of two fibroblast progenitor populations in early explant cultures of hamster gingiva.

Authors:  C A McCulloch; G Knowles
Journal:  Cell Tissue Res       Date:  1991-04       Impact factor: 5.249

Review 6.  Heterogeneity of myofibroblast phenotypic features: an example of fibroblastic cell plasticity.

Authors:  A Schmitt-Gräff; A Desmoulière; G Gabbiani
Journal:  Virchows Arch       Date:  1994       Impact factor: 4.064

7.  Collagen synthesis by human fibroblasts. Regulation by transforming growth factor-beta in the presence of other inflammatory mediators.

Authors:  A S Narayanan; R C Page; J Swanson
Journal:  Biochem J       Date:  1989-06-01       Impact factor: 3.857

8.  Thy-1 expression in human fibroblast subsets defines myofibroblastic or lipofibroblastic phenotypes.

Authors:  Laura Koumas; Terry J Smith; Steven Feldon; Neil Blumberg; Richard P Phipps
Journal:  Am J Pathol       Date:  2003-10       Impact factor: 4.307

9.  The effects of synovial fluid macrophages and interleukin-1 on hyaluronic acid synthesis by normal synovial fibroblasts.

Authors:  K Pulkki
Journal:  Rheumatol Int       Date:  1986       Impact factor: 2.631

Review 10.  Expression of mesenchymal stem cell marker CD90 on dermal sheath cells of the anagen hair follicle in canine species.

Authors:  F Mercati; L Pascucci; P Ceccarelli; C Dall'Aglio; V Pedini; A M Gargiulo
Journal:  Eur J Histochem       Date:  2009-09-30       Impact factor: 3.188
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