Literature DB >> 6607511

Anti-IgA in selective IgA deficiency. In vitro effects and Ig subclass pattern of human anti-IgA.

L Hammarström, M A Persson, C I Smith.   

Abstract

Anti-IgA antibodies were found in 14 of 33 (42%) IgA-deficient donors. In healthy IgA-deficient blood donors anti-IgA appeared associated with the presence of HLA DR3. The antibodies were mainly of the IgG1 and, in high-titred sera, IgG4 subclasses. Sera containing high-titred anti-IgA selectively impaired IgA synthesis in vitro as induced by direct and indirect polyclonal B-cell activators. These antibodies may play a role in the pathogenesis and/or the maintenance of IgA deficiency.

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Year:  1983        PMID： 6607511     DOI： 10.1111/j.1365-3083.1983.tb00885.x

Source DB:  PubMed          Journal:  Scand J Immunol        ISSN： 0300-9475            Impact factor:   3.487


  15 in total

1.  Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency.

Authors:  Ricardo C Ferreira; Qiang Pan-Hammarström; Robert R Graham; Vesela Gateva; Gumersindo Fontán; Annette T Lee; Ward Ortmann; Elena Urcelay; Miguel Fernández-Arquero; Concepción Núñez; Gudmundur Jorgensen; Björn R Ludviksson; Sinikka Koskinen; Katri Haimila; Hilary F Clark; Lars Klareskog; Peter K Gregersen; Timothy W Behrens; Lennart Hammarström
Journal:  Nat Genet       Date:  2010-08-08       Impact factor: 38.330

2.  Long-term follow-up of anti-IgA antibodies in healthy IgA-deficient adults.

Authors:  S Koskinen; H Tölö; M Hirvonen; J Koistinen
Journal:  J Clin Immunol       Date:  1995-07       Impact factor: 8.317

3.  Caucasian origin of disease associated HLA haplotypes in chinese blood donors with IgA deficiency.

Authors:  Ning Wang; Ping Lu; Bing Ling; Ziyan Zhu; Lennart Hammarström
Journal:  J Clin Immunol       Date:  2014-01-09       Impact factor: 8.317

4.  Immunoglobulin A concentrations in commercial immune globulins.

Authors:  R Apfelzweig; D Piszkiewicz; J A Hooper
Journal:  J Clin Immunol       Date:  1987-01       Impact factor: 8.317

5.  In-vitro analysis of defective IgA production in selective IgA deficiency in childhood.

Authors:  N Shinomiya; J Yata
Journal:  Clin Exp Immunol       Date:  1985-12       Impact factor: 4.330

6.  Genetic linkage of IgA deficiency to the major histocompatibility complex: evidence for allele segregation distortion, parent-of-origin penetrance differences, and the role of anti-IgA antibodies in disease predisposition.

Authors:  I Vorechovský; A D Webster; A Plebani; L Hammarström
Journal:  Am J Hum Genet       Date:  1999-04       Impact factor: 11.025

7.  Systemic immunization against IgA in immunoglobulin deficiency.

Authors:  S Mochizuki; C I Smith; R Hällgren; L Hammarström
Journal:  Clin Exp Immunol       Date:  1993-11       Impact factor: 4.330

8.  IgG anti-IgA subclasses in common variable immunodeficiency and association with severe adverse reactions to intravenous immunoglobulin therapy.

Authors:  R de Albuquerque Campos; M N Sato; A J da Silva Duarte
Journal:  J Clin Immunol       Date:  2000-01       Impact factor: 8.317

9.  Anti-IgA antibodies in IgA-deficient children.

Authors:  F H Sennhauser; C S Hosking; C L Jones; R A MacDonald; N Mermelstein; D M Roberton
Journal:  J Clin Immunol       Date:  1988-09       Impact factor: 8.317

10.  Long-term use of IgA-depleted intravenous immunoglobulin in immunodeficient subjects with anti-IgA antibodies.

Authors:  C Cunningham-Rundles; Z Zhou; S Mankarious; S Courter
Journal:  J Clin Immunol       Date:  1993-07       Impact factor: 8.317
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