Literature DB >> 6607472

Rearrangement of a DNA sequence homologous to a cell-virus junction fragment in several Moloney murine leukemia virus-induced rat thymomas.

G Lemay, P Jolicoeur.   

Abstract

We have studied the integrated proviruses in Moloney murine leukemia virus-induced rat thymomas. By Southern blot analysis, we found several complete integrated proviruses in each tumor. In most tumors, we could not detect defective or recombinant proviruses. Several of these integrated proviruses (with their flanking cellular sequences) from a single tumor were cloned in Charon 4A. Their flanking cellular fragments were subcloned into pBR322 and used as a probe to screen other thymoma DNAs. With one clone (pMo-lC) used as a probe, we could detect novel fragments in 11 out of 20 thymoma DNAs analyzed. In three of these thymomas we could analyze in more detail, it appears that these novel fragments are generated by the insertion of a provirus. This specific integration of Moloney provirus in the host genome may represent an important genetic event leading to tumor formation.

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Year:  1984        PMID： 6607472      PMCID： PMC344605          DOI： 10.1073/pnas.81.1.38

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  23 in total

1.  Nucleotide sequence of Moloney murine leukaemia virus.

Authors:  T M Shinnick; R A Lerner; J G Sutcliffe
Journal:  Nature       Date:  1981 Oct 15-21       Impact factor: 49.962

2.  Multiple arrangements of viral DNA and an activated host oncogene in bursal lymphomas.

Authors:  G S Payne; J M Bishop; H E Varmus
Journal:  Nature       Date:  1982-01-21       Impact factor: 49.962

3.  Specific integration of REV proviruses in avian bursal lymphomas.

Authors:  M R Noori-Daloii; R A Swift; H J Kung; L B Crittenden; R L Witter
Journal:  Nature       Date:  1981-12-10       Impact factor: 49.962

4.  Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis.

Authors:  W S Hayward; B G Neel; S M Astrin
Journal:  Nature       Date:  1981-04-09       Impact factor: 49.962

5.  The isolation of structural genes from libraries of eucaryotic DNA.

Authors:  T Maniatis; R C Hardison; E Lacy; J Lauer; C O'Connell; D Quon; G K Sim; A Efstratiadis
Journal:  Cell       Date:  1978-10       Impact factor: 41.582

6.  M-MuLV-induced leukemogenesis: integration and structure of recombinant proviruses in tumors.

Authors:  H van der Putten; W Quint; J van Raaij; E R Maandag; I M Verma; A Berns
Journal:  Cell       Date:  1981-06       Impact factor: 41.582

7.  Analysis of avian leukosis virus DNA and RNA in bursal tumours: viral gene expression is not required for maintenance of the tumor state.

Authors:  G S Payne; S A Courtneidge; L B Crittenden; A M Fadly; J M Bishop; H E Varmus
Journal:  Cell       Date:  1981-02       Impact factor: 41.582

8.  Avian leukosis virus-induced tumors have common proviral integration sites and synthesize discrete new RNAs: oncogenesis by promoter insertion.

Authors:  B G Neel; W S Hayward; H L Robinson; J Fang; S M Astrin
Journal:  Cell       Date:  1981-02       Impact factor: 41.582

9.  Structure of a cloned circular Moloney murine leukemia virus DNA molecule containing an inverted segment: implications for retrovirus integration.

Authors:  C Shoemaker; S Goff; E Gilboa; M Paskind; S W Mitra; D Baltimore
Journal:  Proc Natl Acad Sci U S A       Date:  1980-07       Impact factor: 11.205

10.  On the mechanism of retrovirus-induced avian lymphoid leukosis: deletion and integration of the proviruses.

Authors:  Y K Fung; A M Fadly; L B Crittenden; H J Kung
Journal:  Proc Natl Acad Sci U S A       Date:  1981-06       Impact factor: 11.205
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  42 in total

1.  Viral sequences are associated with many histocompatibility genes.

Authors:  A Rossomando; D Meruelo
Journal:  Immunogenetics       Date:  1986       Impact factor: 2.846

2.  Fim-1, Fim-2/c-fms, and Fim-3, three common integration sites of Friend murine leukemia virus in myeloblastic leukemias, map to mouse chromosomes 13, 18, and 3, respectively.

Authors:  B Sola; D Simon; M G Mattéi; S Fichelson; D Bordereaux; P E Tambourin; J L Guenet; S Gisselbrecht
Journal:  J Virol       Date:  1988-11       Impact factor: 5.103

3.  Effects of translocations on transcription from PVT.

Authors:  E Shtivelman; J M Bishop
Journal:  Mol Cell Biol       Date:  1990-04       Impact factor: 4.272

Review 4.  Provirus tagging as an instrument to identify oncogenes and to establish synergism between oncogenes.

Authors:  A Berns
Journal:  Arch Virol       Date:  1988       Impact factor: 2.574

5.  Tissue selectivity of murine leukemia virus infection is determined by long terminal repeat sequences.

Authors:  C A Rosen; W A Haseltine; J Lenz; R Ruprecht; M W Cloyd
Journal:  J Virol       Date:  1985-09       Impact factor: 5.103

6.  Cellular DNA regions involved in the induction of rat thymic lymphomas (Mlvi-1, Mlvi-2, Mlvi-3, and c-myc) represent independent loci as determined by their chromosomal map location in the rat.

Authors:  P N Tsichlis; M A Lohse; C Szpirer; J Szpirer; G Levan
Journal:  J Virol       Date:  1985-12       Impact factor: 5.103

7.  Insertion of an Alu SINE in the human homologue of the Mlvi-2 locus.

Authors:  A Economou-Pachnis; P N Tsichlis
Journal:  Nucleic Acids Res       Date:  1985-12-09       Impact factor: 16.971

8.  The PVT gene frequently amplifies with MYC in tumor cells.

Authors:  E Shtivelman; J M Bishop
Journal:  Mol Cell Biol       Date:  1989-03       Impact factor: 4.272

9.  Mouse chromosomal mapping of a murine leukemia virus integration region (Mis-1) first identified in rat thymic leukemia.

Authors:  P Jolicoeur; L Villeneuve; E Rassart; C Kozak
Journal:  J Virol       Date:  1985-12       Impact factor: 5.103

10.  Proviral integration site Mis-1 in rat thymomas corresponds to the pvt-1 translocation breakpoint in murine plasmacytomas.

Authors:  L Villeneuve; E Rassart; P Jolicoeur; M Graham; J M Adams
Journal:  Mol Cell Biol       Date:  1986-05       Impact factor: 4.272
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