| Literature DB >> 6607395 |
E M Unterwald, L T Kucharski, J E Williams, C Kornetsky.
Abstract
Thresholds for reinforcing electrical stimulation to the medial forebrain bundle were determined in rats by means of a rate-free psychophysical method. The acute administration of tripelennamine lowered the threshold for rewarding brain stimulation in a dose-dependent manner. These results suggest that the abuse liability of tripelennamine may be related to its ability to sensitize the central neural pathway that mediates reward.Entities:
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Year: 1984 PMID： 6607395 DOI： 10.1016/0024-3205(84)90585-x
Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037