Literature DB >> 6607029

Biological profile and response to anti-pneumocystis agents of Pneumocystis carinii in cell culture.

L L Pifer, D D Pifer, D R Woods.   

Abstract

Although the growth characteristics of Pneumocystis carinii have been described in several cell culture systems, the response of this organism to the drugs of choice, trimethoprim-sulfamethoxazole and pentamidine isethionate, have not been described in vitro. The effect of various concentrations of drugs against P. carinii on the growth of this potentially hazardous opportunistic organism as well as the methodology for in vitro assay of these agents have been detailed. Fluorescence profiles illustrating size ranges of trophozoites and cysts derived from cell culture are described.

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Year:  1983        PMID： 6607029      PMCID： PMC185923          DOI： 10.1128/AAC.24.5.674

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  14 in total

1.  Propagation of Pneumocystis carinii in Vero cell culture.

Authors:  L L Pifer; D Woods; W T Hughes
Journal:  Infect Immun       Date:  1978-04       Impact factor: 3.441

2.  Latent Pneumocystis infection of rats, relapse, and chemotherapy.

Authors:  J K Frenkel; J T Good; J A Shultz
Journal:  Lab Invest       Date:  1966-10       Impact factor: 5.662

3.  Propagation of Pneumocystis carinii in vitro.

Authors:  L L Pifer; W T Hughes; M J Murphy
Journal:  Pediatr Res       Date:  1977-04       Impact factor: 3.756

4.  Pneumocystis pneumonia: a plague of the immunosuppressed.

Authors:  W T Hughes
Journal:  Johns Hopkins Med J       Date:  1978-12

5.  Serial propagation of Pneumocystis carinii in cell line cultures.

Authors:  C R Latorre; A J Sulzer; L G Norman
Journal:  Appl Environ Microbiol       Date:  1977-05       Impact factor: 4.792

6.  Cultivation of Pneumocystis carinii with WI-38 cells.

Authors:  M S Bartlett; P A Verbanac; J W Smith
Journal:  J Clin Microbiol       Date:  1979-12       Impact factor: 5.948

7.  Limited effect of trimethoprim-sulfamethoxazole prophylaxis on Pneumocystis carinii.

Authors:  W T Hughes
Journal:  Antimicrob Agents Chemother       Date:  1979-09       Impact factor: 5.191

8.  Fractionation of Pneumocystis carinii antigens used in an enzyme-linked immunosorbent assay for antibodies and in the production of antiserum for detecting Pneumocystis carinii antigenemia.

Authors:  S E Maddison; G V Hayes; M H Ivey; V C Tsang; S B Slemenda; L G Norman
Journal:  J Clin Microbiol       Date:  1982-06       Impact factor: 5.948

9.  Metabolic and synthetic activities of Pneumocystis carinii in vitro.

Authors:  E L Pesanti; C Cox
Journal:  Infect Immun       Date:  1981-12       Impact factor: 3.441

10.  Successful chemoprophylaxis for Pneumocystis carinii pneumonitis.

Authors:  W T Hughes; S Kuhn; S Chaudhary; S Feldman; M Verzosa; R J Aur; C Pratt; S L George
Journal:  N Engl J Med       Date:  1977-12-29       Impact factor: 91.245
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  9 in total

Review 1.  Inhaled pentamidine. An overview of its pharmacological properties and a review of its therapeutic use in Pneumocystis carinii pneumonia.

Authors:  J P Monk; P Benfield
Journal:  Drugs       Date:  1990-05       Impact factor: 9.546

2.  In vitro pharmacodynamic parameters of sordarin derivatives in comparison with those of marketed compounds against Pneumocystis carinii isolated from rats.

Authors:  P Aviles; E M Aliouat; A Martinez; E Dei-Cas; E Herreros; L Dujardin; D Gargallo-Viola
Journal:  Antimicrob Agents Chemother       Date:  2000-05       Impact factor: 5.191

3.  Quantification and assessment of viability of Pneumocystis carinii organisms by flow cytometry.

Authors:  S E Lapinsky; D Glencross; N G Car; J M Kallenbach; S Zwi
Journal:  J Clin Microbiol       Date:  1991-05       Impact factor: 5.948

4.  In vitro differentiation of human-derived Pneumocystis carinii.

Authors:  W Blumenfeld; J M Griffiss
Journal:  J Clin Microbiol       Date:  1989-03       Impact factor: 5.948

5.  "Pneumocystis carinii"--a misunderstood enigma.

Authors:  W Beautyman
Journal:  Eur J Clin Microbiol       Date:  1984-12       Impact factor: 3.267

Review 6.  Pneumocystis carinii: a misunderstood opportunist.

Authors:  L L Pifer
Journal:  Eur J Clin Microbiol       Date:  1984-06       Impact factor: 3.267

Review 7.  Pentamidine isethionate. A review of its antiprotozoal activity, pharmacokinetic properties and therapeutic use in Pneumocystis carinii pneumonia.

Authors:  K L Goa; D M Campoli-Richards
Journal:  Drugs       Date:  1987-03       Impact factor: 9.546

8.  Microculture screening assay for primary in vitro evaluation of drugs against Pneumocystis carinii.

Authors:  J C Comley; R J Mullin; L A Wolfe; M H Hanlon; R Ferone
Journal:  Antimicrob Agents Chemother       Date:  1991-10       Impact factor: 5.191

9.  Method of testing the susceptibility of Pneumocystis carinii to antimicrobial agents in vitro.

Authors:  M T Cushion; D Stanforth; M J Linke; P D Walzer
Journal:  Antimicrob Agents Chemother       Date:  1985-12       Impact factor: 5.191
  9 in total

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