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Literature DB >> 6605928

Soluble peptidoglycan from Staphylococcus aureus is a murine B-lymphocyte mitogen.

Abstract

Soluble peptidoglycan from Staphylococcus aureus has been shown to be capable of causing murine B lymphocytes from the spleen to proliferate and to secrete immunoglobulins in both an in vitro and an in vivo assay. The optimal concentration in vitro was between 33 and 100 micrograms/ml. A 3-day incubation with soluble peptidoglycan was more stimulatory than was a 1- or 2-day incubation. Removal of most of the T lymphocytes with anti-theta serum did not result in any significant change in the mitogenic activity of soluble peptidoglycan on the remaining B cells.

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Year: 1983 PMID： 6605928 PMCID： PMC264400 DOI： 10.1128/iai.42.3.1013-1016.1983

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

17 in total

1. Biological properties of the peptidoglycan.

Authors: B Heymer
Journal: Z Immunitatsforsch Exp Klin Immunol Date: 1975-07

2. Peptidoglycan synthesis in Bacillus licheniformis. The inhibition of cross-linking by benzylpenicillin and cephaloridine in vivo accompanied by the formation of soluble peptidoglycan.

Authors: Z Tynecka; J B Ward
Journal: Biochem J Date: 1975-01 Impact factor: 3.857

3. Plaque assay for the detection of alloantibody-producing cells in mice.

Authors: A K Wong; E Sabbadini
Journal: J Immunol Date: 1974-06 Impact factor: 5.422

4. Penicillin-induced secretion of soluble, uncross-linked peptidoglycan by Micrococcus luteus cells.

Authors: D Mirelman; R Bracha; N Sharon
Journal: Biochemistry Date: 1974-11-19 Impact factor: 3.162

5. Evidence for the synthesis of soluble peptidoglycan fragments by protoplasts of Streptococcus faecalis.

Authors: R S Rosenthal; D Jungkind; L Daneo-Moore; G D Shockman
Journal: J Bacteriol Date: 1975-10 Impact factor: 3.490

6. A plaque assay for all cells secreting Ig of a given type or class.

Authors: E Gronowicz; A Coutinho; F Melchers
Journal: Eur J Immunol Date: 1976-08 Impact factor: 5.532

7. Antibodies against a synthetic peptidoglycan-precursor pentapeptide cross-react with at least two distinct populations of uncross-linked soluble peptidoglycan secreted by Micrococcus luteus cells.

Authors: A R Zeiger; S M Eaton; D Mirelman
Journal: Eur J Biochem Date: 1978-05

8. Immunoadjuvant activities of cell walls, their water-soluble fractions and peptidoglycan subunits, prepared from various gram-positive bacteria, and of synthetic n-acetylmuramyl peptides.

Authors: S Kotani; Y Watanabe; T Shimono; T Narita; K Kato
Journal: Z Immunitatsforsch Exp Klin Immunol Date: 1975-07

Soluble peptidoglycan from Staphylococcus aureus is a murine B-lymphocyte mitogen.

1. Biological properties of the peptidoglycan.

2. Peptidoglycan synthesis in Bacillus licheniformis. The inhibition of cross-linking by benzylpenicillin and cephaloridine in vivo accompanied by the formation of soluble peptidoglycan.

3. Plaque assay for the detection of alloantibody-producing cells in mice.

4. Penicillin-induced secretion of soluble, uncross-linked peptidoglycan by Micrococcus luteus cells.

5. Evidence for the synthesis of soluble peptidoglycan fragments by protoplasts of Streptococcus faecalis.

6. A plaque assay for all cells secreting Ig of a given type or class.

7. Antibodies against a synthetic peptidoglycan-precursor pentapeptide cross-react with at least two distinct populations of uncross-linked soluble peptidoglycan secreted by Micrococcus luteus cells.

8. Immunoadjuvant activities of cell walls, their water-soluble fractions and peptidoglycan subunits, prepared from various gram-positive bacteria, and of synthetic n-acetylmuramyl peptides.

9. Endotoxin-like properties of the peptidoglycan.

10. Evidence for the secretion of soluble peptidoglycans by clinical isolates of Staphylococcus aureus.

1. Soluble non-cross-linked peptidoglycan polymers stimulate monocyte-macrophage inflammatory functions.

2. Lysozyme-mediated aggregation and lysis of the periodontal microorganism Capnocytophaga gingivalis 2010.

3. Anthrax toxin blocks priming of neutrophils by lipopolysaccharide and by muramyl dipeptide.