Literature DB >> 6605479

Tumorigenicity of cells transformed by adenovirus type 12 by evasion of T-cell immunity.

R Bernards, P I Schrier, A Houweling, J L Bos, A J van der Eb, M Zijlstra, C J Melief.   

Abstract

Evidence is presented that cells transformed by adenovirus type 12 are oncogenic because they escape from T-cell immunity. This effect is brought about by reducing the expression of class I transplantation antigens and is a function of the protein translated from the 13S mRNA, transcribed from early region 1a. These findings establish a novel mechanism by which transformed cells can acquire an oncogenic phenotype.

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Year:  1983        PMID： 6605479     DOI： 10.1038/305776a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  107 in total

1.  The N terminus of adenovirus type 12 E1A inhibits major histocompatibility complex class I expression by preventing phosphorylation of NF-kappaB p65 Ser276 through direct binding.

Authors:  Junfang Jiao; Hancheng Guan; Andrew M Lippa; Robert P Ricciardi
Journal:  J Virol       Date:  2010-05-26       Impact factor: 5.103

2.  Modulation of MHC antigen expression by viruses and oncogenes.

Authors:  D J Maudsley; J D Pound
Journal:  Immunol Today       Date:  1991-12

3.  HLA class I homologous transcripts in the human embryonal carcinoma cell line Tera-2.

Authors:  T F Rinke de Wit; L Struyk; S Vloemans; J Glazebrook; J M Boyle; P L Stern; P J van den Elsen
Journal:  Immunogenetics       Date:  1990       Impact factor: 2.846

4.  Phosphorylation in vitro of Escherichia coli-produced 235R and 266R tumor antigens encoded by human adenovirus type 12 early transformation region 1A.

Authors:  L A Lucher; P M Loewenstein; M Green
Journal:  J Virol       Date:  1985-10       Impact factor: 5.103

5.  Identification of adenovirus 12-encoded E1A tumor antigens synthesized in infected and transformed mammalian cells and in Escherichia coli.

Authors:  L A Lucher; D Kimelman; J S Symington; K H Brackmann; M A Cartas; H Thornton; M Green
Journal:  J Virol       Date:  1984-10       Impact factor: 5.103

Review 6.  The human immunodeficiency virus type 1 (HIV-1) CD4 receptor and its central role in promotion of HIV-1 infection.

Authors:  S Bour; R Geleziunas; M A Wainberg
Journal:  Microbiol Rev       Date:  1995-03

7.  Production of a monospecific antiserum against the early region 1A proteins of adenovirus 12 and adenovirus 5 by an adenovirus 12 early region 1A-beta-galactosidase fusion protein antigen expressed in bacteria.

Authors:  M O Scott; D Kimelman; D Norris; R P Ricciardi
Journal:  J Virol       Date:  1984-06       Impact factor: 5.103

8.  Murine leukemia virus sequences are encoded in the murine major histocompatibility complex.

Authors:  D Meruelo; R Kornreich; A Rossomando; C Pampeno; A L Mellor; E H Weiss; R A Flavell; A Pellicer
Journal:  Proc Natl Acad Sci U S A       Date:  1984-03       Impact factor: 11.205

9.  Oncogenicity by adenovirus is not determined by the transforming region only.

Authors:  R Bernards; M G de Leeuw; M J Vaessen; A Houweling; A J van der Eb
Journal:  J Virol       Date:  1984-06       Impact factor: 5.103

10.  Expression of the E4 gene is required for establishment of soft-agar colony-forming rat cell lines transformed by the adenovirus 12 E1 gene.

Authors:  K Shiroki; S Hashimoto; I Saito; Y Fukui; Y Fukui; H Kato; H Shimojo
Journal:  J Virol       Date:  1984-06       Impact factor: 5.103
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