Literature DB >> 6604933

Antagonism by tomoxetine of the depletion of norepinephrine and epinephrine in rat brain by alpha-methyl-m-tyrosine.

R W Fuller, S K Hemrick-Luecke.   

Abstract

Tomoxetine hydrochloride, a potential antidepressant drug, antagonized the alpha-methyl-m-tyrosine-induced depletion of hypothalamic epinephrine and norepinephrine in rats. The findings suggest that tomoxetine, like several uptake-inhibiting antidepressant drugs that have been examined, inhibits uptake into epinephrine neurons as well as norepinephrine neurons in brain.

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Year:  1983        PMID: 6604933

Source DB:  PubMed          Journal:  Res Commun Chem Pathol Pharmacol        ISSN: 0034-5164


  4 in total

Review 1.  Spotlight on atomoxetine in adults with attention-deficit hyperactivity disorder.

Authors:  Dene Simpson; Greg L Plosker
Journal:  CNS Drugs       Date:  2004       Impact factor: 5.749

Review 2.  Atomoxetine.

Authors:  Dene Simpson; Caroline M Perry
Journal:  Paediatr Drugs       Date:  2003       Impact factor: 3.022

Review 3.  Atomoxetine: a review of its use in adults with attention deficit hyperactivity disorder.

Authors:  Dene Simpson; Greg L Plosker
Journal:  Drugs       Date:  2004       Impact factor: 9.546

Review 4.  Clinical pharmacokinetics of atomoxetine.

Authors:  John-Michael Sauer; Barbara J Ring; Jennifer W Witcher
Journal:  Clin Pharmacokinet       Date:  2005       Impact factor: 5.577

  4 in total

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