| Literature DB >> 660491 |
F A Weaver, A R Torkelson, W A Zygmunt, H P Browder.
Abstract
An in vitro cytotoxicity assay for cyclophosphamide metabolites in rat body fluids is described. Of the two tissue culture tumor cell lines employed, the Walker-256 rat carcinosarcoma was more sensitive to metabolite levels than the L-1210 mouse lymphocytic leukemia. The Walker-256 system detected cyclophosphamide metabolite levels two orders of magnitude lower than the commonly used 4-(p-nitrobenzyl)pyridine analytical procedure.Entities:
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Year: 1978 PMID： 660491 DOI： 10.1002/jps.2600670738
Source DB: PubMed Journal: J Pharm Sci ISSN： 0022-3549 Impact factor: 3.534