Association of Guillain-Barre syndrome and B-virus hepatitis: simultaneous presence of anti-DS-DNA antibodies and HBs antigen in cerebrospinal-fluid.

HBs antigen was found in the cerebrospinal fluid of a patient with acute type B virus hepatitis and Guillain-Barré syndrome. At the onset of the neurologic disease, immunological study of the spinal fluid revealed local synthesis of immunoglobulins and, in particular, anti-double-stranded DNA IgG antibodies. These abnormalities disappeared when the neurologic syndrome remitted. These findings suggest the extension of viral aggression to the central nervous system, perhaps at the onset of the neurologic disease.