Literature DB >> 6603428

Radiofluorination with xenon difluoride: a new high yield synthesis of [18F]2-fluro-2-deoxy-D-glucose.

S Sood, G Firnau, E S Garnett.   

Abstract

The reaction between [18F]xenon difluoride, 3,4,6-tri-O-acetyl-D-glucal and boron trifluoride in ether gives exclusively [18F )3,4,6-tri-O-acetyl-2-fluoro-2-deoxy-D-glucopyranosyl fluoride, which is hydrolysed with 1 N HCl to [18F]2-fluoro-2-deoxy-D-glucose. The overall chemical yield is 75%; the radiochemical yield is 20%. The procedure takes 45 min.

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Year:  1983        PMID: 6603428     DOI: 10.1016/0020-708x(83)90254-5

Source DB:  PubMed          Journal:  Int J Appl Radiat Isot        ISSN: 0020-708X


  6 in total

1.  Synthesis of [F]Xenon Difluoride as a Radiolabeling Reagent from [F]Fluoride Ion in a Micro-reactor and at Production Scale.

Authors:  Shuiyu Lu; Victor W Pike
Journal:  J Fluor Chem       Date:  2010-10-01       Impact factor: 2.050

2.  Fluorine-18: an untapped resource in inorganic chemistry.

Authors:  Cassis Varlow; Daniel Szames; Kenneth Dahl; Vadim Bernard-Gauthier; Neil Vasdev
Journal:  Chem Commun (Camb)       Date:  2018-10-18       Impact factor: 6.222

Review 3.  Radiosyntheses using fluorine-18: the art and science of late stage fluorination.

Authors:  Erin L Cole; Megan N Stewart; Ryan Littich; Raphael Hoareau; Peter J H Scott
Journal:  Curr Top Med Chem       Date:  2014       Impact factor: 3.295

4.  Synthesis and biodistribution of 2-deoxy-2-[18F]fluoro-D-glucopyranosyl [18F]fluoride in mice.

Authors:  C Y Shiue; C D Arnett; A P Wolf
Journal:  Eur J Nucl Med       Date:  1984

5.  Total Radiosynthesis: Thinking outside "the box".

Authors:  Steven H Liang; Neil Vasdev
Journal:  Aust J Chem       Date:  2015-08-28       Impact factor: 1.321

6.  Synthesis of 2-deoxy-2-[82Br]bromo-D-mannose and related compounds and their biodistributions in mice.

Authors:  Y G Zhou; C Y Shiue; A P Wolf; C D Arnett
Journal:  Eur J Nucl Med       Date:  1985
  6 in total

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