Literature DB >> 6602382

Structure of a mouse submaxillary messenger RNA encoding epidermal growth factor and seven related proteins.

J Scott, M Urdea, M Quiroga, R Sanchez-Pescador, N Fong, M Selby, W J Rutter, G I Bell.   

Abstract

The structure of the messenger RNA (mRNA) encoding the precursor to mouse submaxillary epidermal growth factor (EGF) was determined from the sequence of a set of overlapping complementary DNA's (cDNA). The mRNA is unexpectedly large, about 4750 nucleotide bases, and predicts the sequence of preproEGF, a protein of 1217 amino acids (133,000 molecular weight). The EGF moiety (53 amino acids) is flanked by polypeptide segments of 976 and 188 amino acids at its amino and carboyxl termini, respectively. The amino terminal segment of the precursor contains seven peptides with sequences that are similar but not identical to EGF.

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Year:  1983        PMID： 6602382     DOI： 10.1126/science.6602382

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  72 in total

1.  Molecular basis of loss-of-function mutations in the glp-1 gene of Caenorhabditis elegans.

Authors:  V Kodoyianni; E M Maine; J Kimble
Journal:  Mol Biol Cell       Date:  1992-11       Impact factor: 4.138

2.  A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains.

Authors:  J Partanen; E Armstrong; T P Mäkelä; J Korhonen; M Sandberg; R Renkonen; S Knuutila; K Huebner; K Alitalo
Journal:  Mol Cell Biol       Date:  1992-04       Impact factor: 4.272

Review 3.  Notch and the awesome power of genetics.

Authors:  Iva Greenwald
Journal:  Genetics       Date:  2012-07       Impact factor: 4.562

4.  Involvement of transforming growth factor alpha in the release of luteinizing hormone-releasing hormone from the developing female hypothalamus.

Authors:  S R Ojeda; H F Urbanski; M E Costa; D F Hill; M Moholt-Siebert
Journal:  Proc Natl Acad Sci U S A       Date:  1990-12       Impact factor: 11.205

5.  Sequence of the notch locus of Drosophila melanogaster: relationship of the encoded protein to mammalian clotting and growth factors.

Authors:  S Kidd; M R Kelley; M W Young
Journal:  Mol Cell Biol       Date:  1986-09       Impact factor: 4.272

6.  Ultrastructural localization of the putative precursors of the A4 amyloid protein associated with Alzheimer's disease.

Authors:  N Catteruccia; J Willingale-Theune; D Bunke; R Prior; C L Masters; A Crisanti; K Beyreuther
Journal:  Am J Pathol       Date:  1990-07       Impact factor: 4.307

7.  Differential expression of transforming growth factors alpha and beta in rat intestinal epithelial cells.

Authors:  S Y Koyama; D K Podolsky
Journal:  J Clin Invest       Date:  1989-05       Impact factor: 14.808

8.  Structural analysis of the uEGF gene in the sea urchin strongylocentrotus purpuratus reveals more similarity to vertebrate than to invertebrate genes with EGF-like repeats.

Authors:  M G Delgadillo-Reynoso; D R Rollo; D A Hursh; R A Raff
Journal:  J Mol Evol       Date:  1989-10       Impact factor: 2.395

9.  Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains.

Authors:  V Bhandari; R G Palfree; A Bateman
Journal:  Proc Natl Acad Sci U S A       Date:  1992-03-01       Impact factor: 11.205

10.  Prediction of the three-dimensional structures of the nerve growth factor and epidermal growth factor binding proteins (kallikreins) and an hypothetical structure of the high molecular weight complex of epidermal growth factor with its binding protein.

Authors:  B Bax; M Blaber; G Ferguson; M J Sternberg; P H Walls
Journal:  Protein Sci       Date:  1993-08       Impact factor: 6.725
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