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Literature DB >> 6601062

Susceptibility of congenitally athymic (nude) mice to sporotrichosis.

Abstract

Congenitally athymic (nu/nu) mice were found to be more susceptible to intravenous challenge with Sporothrix schenckii than their phenotypically normal (nu/+) littermates as measured by lethality and the number of viable yeast cells in the liver 7 days postinfection. Thymus reconstitution of nu/nu mice (nu/thy) conferred a significant degree of resistance to sporotrichosis. Immunization greatly enhanced the resistance of nu/thy and nu/+ mice, but unexpectedly increased the susceptibility of nu/nu mice. The susceptibility of nonimmunized nu/nu mice and the finding that thymus transplants augmented resistance to sporotrichosis suggest that T lymphocytes are critical to host defense.

Entities: Disease Species

Mesh：

Year: 1983 PMID： 6601062 PMCID： PMC264863 DOI： 10.1128/iai.40.1.417-420.1983

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

11 in total

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Journal: J Reticuloendothel Soc Date: 1979-09

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Journal: Ann Surg Date: 1980-12 Impact factor: 12.969

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13 in total

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Authors: D M Dixon; R A Duncan; N J Hurd
Journal: J Clin Microbiol Date: 1992-04 Impact factor: 5.948

Review 2. Thermally Dimorphic Human Fungal Pathogens--Polyphyletic Pathogens with a Convergent Pathogenicity Trait.

Authors: Anita Sil; Alex Andrianopoulos
Journal: Cold Spring Harb Perspect Med Date: 2014-11-10 Impact factor: 6.915

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Journal: Infect Immun Date: 1985-03 Impact factor: 3.441

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Authors: Hideko Kajiwara; Mitsumasa Saito; Shouichi Ohga; Takeshi Uenotsuchi; Shin-ichi Yoshida
Journal: Infect Immun Date: 2004-09 Impact factor: 3.441

5. Histopathological studies of Sporothrix schenckii-inoculated mice. Possible functions of polymorphonuclear leukocytes in normal and immunocompromised (congenitally athymic nude) mice.

Authors: P C Lei; T Yoshiike; H Yaguchi; H Ogawa
Journal: Mycopathologia Date: 1993-05 Impact factor: 2.574

6. Characterisation of peripheral blood mononuclear cell populations in periparturient dairy cows that develop metritis.

Authors: John J Bromfield; Meghan M Watt; Sossi M Iacovides
Journal: Vet Immunol Immunopathol Date: 2018-04-30 Impact factor: 2.046

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Authors: Karla Simone S Fernandes; Edward Helal Neto; Marcelly M S Brito; João S Silva; Fernando Q Cunha; Christina Barja-Fidalgo
Journal: Immunology Date: 2008-01-09 Impact factor: 7.397

9. Response of Cytokines and Hydrogen Peroxide to Sporothrix schenckii Exoantigen in Systemic Experimental Infection.

Authors: Danielle Cardoso Geraldo Maia; Amanda Costa Gonçalves; Lucas Souza Ferreira; Francine Alessandra Manente; Deivys Leandro Portuondo; José Carlos Rebuglio Vellosa; Marisa Campos Polesi; Alexander Batista-Duharte; Iracilda Zeppone Carlos
Journal: Mycopathologia Date: 2015-11-24 Impact factor: 2.574

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Authors: Carlos A Alba-Fierro; Armando Pérez-Torres; Conchita Toriello; Yolanda Romo-Lozano; Everardo López-Romero; Estela Ruiz-Baca
Journal: Curr Microbiol Date: 2016-04-27 Impact factor: 2.188