Literature DB >> 6600707

Studies on T lymphocyte activation. II. Monoclonal antibody inhibiting the capacity of rat T lymphoblasts to absorb and to respond to IL-2: an anti-IL-2 receptor antibody?

H Osawa, T Diamantstein.   

Abstract

We describe the production and some of the properties of a monoclonal antibody which inhibits binding of Interleukin 2 (IL-2) to rat T lymphoblasts as well as the capacity of these lymphoblasts to proliferate in response to IL-2 of rat or murine origin. According to these criteria, the antibody seems to be directed against an antigenic determinant on the IL-2 receptor. The antibody, obtained from hybridomas derived from mice immunized with phorbol-myristate-acetate-pulsed rat T lymphoblasts, exhibited species specificity, indicating that IL-2 receptors of various species are not necessarily identical, even if they can respond to IL-2 from different species.

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Year:  1983        PMID： 6600707      PMCID： PMC1454026     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  9 in total

1.  Continuous cultures of fused cells secreting antibody of predefined specificity.

Authors:  G Köhler; C Milstein
Journal:  Nature       Date:  1975-08-07       Impact factor: 49.962

2.  Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using protein A-sepharose.

Authors:  P L Ey; S J Prowse; C R Jenkin
Journal:  Immunochemistry       Date:  1978-07

3.  T-cell growth factor-mediated T-cell proliferation.

Authors:  K A Smith; S Gillis; P E Baker; D McKenzie; F W Ruscetti
Journal:  Ann N Y Acad Sci       Date:  1979       Impact factor: 5.691

4.  The role of mitogenic lectins in T-cell triggering.

Authors:  E L Larsson; A Coutinho
Journal:  Nature       Date:  1979-07-19       Impact factor: 49.962

5.  "Self-reactive" T cells. I. In vivo reaction of T cells to transferred polyclonally activated syngeneic and autologous lymphoblasts.

Authors:  J Reimann; T Diamantstein
Journal:  Immunobiology       Date:  1980-12       Impact factor: 3.144

6.  Hybrid cell lines secreting monoclonal antibody specific for major histocompatibility antigens of the mouse.

Authors:  H Lemke; G J Hammerling; C Hohmann; K Rajewsky
Journal:  Nature       Date:  1978-01-19       Impact factor: 49.962

7.  Assays for cellular antigens in the presence of detergents.

Authors:  A F Williams
Journal:  Eur J Immunol       Date:  1973-10       Impact factor: 5.532

8.  Studies on T-lymphocyte activation. I. Is competence inductions in thymocytes by phorbol myristate acetate, an accessory cell-independent event?

Authors:  T Diamantstein; M Klos; J Reimann
Journal:  Immunology       Date:  1981-05       Impact factor: 7.397

9.  T cell growth factor receptors. Quantitation, specificity, and biological relevance.

Authors:  R J Robb; A Munck; K A Smith
Journal:  J Exp Med       Date:  1981-11-01       Impact factor: 14.307
  9 in total
  3 in total

1.  Gamma interferon treatment in vivo provokes accumulation of activated monocytes in the venous circulation of rats.

Authors:  B Steiniger; D Schröder; R Lück; L Luciano; P H van der Meide
Journal:  Am J Pathol       Date:  1990-04       Impact factor: 4.307

2.  Therapy with monoclonal antibody to interleukin 2 receptor spares suppressor T cells and prevents or reverses acute allograft rejection in rats.

Authors:  J W Kupiec-Weglinski; T Diamantstein; N L Tilney; T B Strom
Journal:  Proc Natl Acad Sci U S A       Date:  1986-04       Impact factor: 11.205

3.  Interleukin 2 and a lactogen regulate proliferation and protein phosphorylation in Nb2 cells.

Authors:  E J Rayhel; T J Fields; J W Albright; T Diamantstein; J P Hughes
Journal:  Biochem J       Date:  1988-01-15       Impact factor: 3.857
  3 in total

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