Literature DB >> 6596795

Understanding genetic and environmental risk factors in susceptible persons.

R R Williams.   

Abstract

Most major chronic diseases probably result from environmental factors accumulating over time in genetically susceptible persons. A detailed family history assessment can help identify the subset of the general population with a strong predisposition to certain major diseases. An understanding of the environmental factors promoting disease development will facilitate more effective prevention or delay disease in a targeted susceptible population. To effectively use this growing knowledge in genetics and epidemiology, health professionals need to motivate people to follow sound recommendations for preventing and delaying disease.To increase the efficiency and effectiveness of strategies for health promotion and disease prevention, family history data can help determine those diseases for which persons have the greatest risk. They can then concentrate their primary efforts on those preventive measures that will most likely benefit them.

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Year:  1984        PMID： 6596795      PMCID： PMC1011214     

Source DB:  PubMed          Journal:  West J Med        ISSN： 0093-0415


  13 in total

1.  Case-control study of antihypertensive and diuretic use by women with malignant and benign breast lesions detected in a mammography screening program.

Authors:  R R Williams; M Feinleib; R J Connor; N L Stegens
Journal:  J Natl Cancer Inst       Date:  1978-08       Impact factor: 13.506

Review 2.  Etiology of human breast cancer: a review.

Authors:  B MacMahon; P Cole; J Brown
Journal:  J Natl Cancer Inst       Date:  1973-01       Impact factor: 13.506

3.  Utah pedigree studies: design and preliminary data for premature male CHD deaths.

Authors:  R R Williams; M Skolnick; D Carmelli; A T Maness; S C Hunt; S Hasstedt; G E Reiber; R K Jones
Journal:  Prog Clin Biol Res       Date:  1979

4.  Breast cancer risk factors among screening program participants.

Authors:  L A Brinton; R R Williams; R N Hoover; N L Stegens; M Feinleib; J F Fraumeni
Journal:  J Natl Cancer Inst       Date:  1979-01       Impact factor: 13.506

5.  Prevention of coronary heart disease by cholesterol lowering diet.

Authors:  M Miettinen
Journal:  Postgrad Med J       Date:  1975       Impact factor: 2.401

6.  Hereditary hemochromatosis. Diagnosis in siblings and children.

Authors:  C Q Edwards; M Carroll; P Bray; G E Cartwright
Journal:  N Engl J Med       Date:  1977-07-07       Impact factor: 91.245

7.  Epidemiologic studies of coronary heart disease and stroke in Japanese men living in Japan, Hawaii and California: prevalence of coronary and hypertensive heart disease and associated risk factors.

Authors:  M G Marmot; S L Syme; A Kagan; H Kato; J B Cohen; J Belsky
Journal:  Am J Epidemiol       Date:  1975-12       Impact factor: 4.897

8.  Breast cancer and reproductive history from genealogical data.

Authors:  S C Hunt; R R Williams; M H Skolnick; J L Lyon; C R Smart
Journal:  J Natl Cancer Inst       Date:  1980-05       Impact factor: 13.506

9.  Screening for colorectal cancer: an overview.

Authors:  S J Winawer
Journal:  Cancer       Date:  1980-03-15       Impact factor: 6.860

10.  Association of cancer sites with tobacco and alcohol consumption and socioeconomic status of patients: interview study from the Third National Cancer Survey.

Authors:  R R Williams; J W Horm
Journal:  J Natl Cancer Inst       Date:  1977-03       Impact factor: 13.506
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  7 in total

Review 1.  Gene environment interaction.

Authors:  H Campbell
Journal:  J Epidemiol Community Health       Date:  1996-08       Impact factor: 3.710

2.  Relation of subclinical coronary artery atherosclerosis to cerebral white matter disease in healthy subjects from families with early-onset coronary artery disease.

Authors:  Brian G Kral; Paul Nyquist; Dhananjay Vaidya; David Yousem; Lisa R Yanek; Elliot K Fishman; Lewis C Becker; Diane M Becker
Journal:  Am J Cardiol       Date:  2013-06-03       Impact factor: 2.778

3.  Silent myocardial ischaemia and long-term coronary artery disease outcomes in apparently healthy people from families with early-onset ischaemic heart disease.

Authors:  Brian G Kral; Lewis C Becker; Dhananjay Vaidya; Lisa R Yanek; Diane M Becker
Journal:  Eur Heart J       Date:  2011-07-23       Impact factor: 29.983

4.  Incidence of coronary artery disease in siblings of patients with premature coronary artery disease: 10 years of follow-up.

Authors:  Dhananjay Vaidya; Lisa R Yanek; Taryn F Moy; Thomas A Pearson; Lewis C Becker; Diane M Becker
Journal:  Am J Cardiol       Date:  2007-08-16       Impact factor: 2.778

5.  Noncalcified coronary plaque volumes in healthy people with a family history of early onset coronary artery disease.

Authors:  Brian G Kral; Lewis C Becker; Dhananjay Vaidya; Lisa R Yanek; Rehan Qayyum; Stefan L Zimmerman; Damini Dey; Daniel S Berman; Taryn F Moy; Elliot K Fishman; Diane M Becker
Journal:  Circ Cardiovasc Imaging       Date:  2014-02-27       Impact factor: 7.792

6.  Health family trees: a tool for finding and helping young family members of coronary and cancer prone pedigrees in Texas and Utah.

Authors:  R R Williams; S C Hunt; G K Barlow; R M Chamberlain; A D Weinberg; H P Cooper; J P Carbonari; A M Gotto
Journal:  Am J Public Health       Date:  1988-10       Impact factor: 9.308

7.  A common variant in the CDKN2B gene on chromosome 9p21 protects against coronary artery disease in Americans of African ancestry.

Authors:  Brian G Kral; Rasika A Mathias; Bhoom Suktitipat; Ingo Ruczinski; Dhananjay Vaidya; Lisa R Yanek; Arshed A Quyyumi; Riyaz S Patel; A Maziar Zafari; Viola Vaccarino; Elizabeth R Hauser; William E Kraus; Lewis C Becker; Diane M Becker
Journal:  J Hum Genet       Date:  2011-01-27       Impact factor: 3.172
  7 in total

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