Literature DB >> 6595988

Decreased blood levels of ethanol and acetaldehyde by S-adenosyl-L-methionine in humans.

C Di Padova, R Tritapepe, P Rovagnati, M Pozzoli, G Stramentinoli.   

Abstract

In view of the protective effects of SAM on alcohol-induced fatty liver degeneration, an investigation has been carried out to see if this compound accelerates the clearance of ethanol and acetaldehyde in humans. Both parameters were significantly lower after SAM, indicating the capability of exogenous SAM to favour the inactivation of ethanol without increasing blood levels of acetaldehyde.

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Year:  1984        PMID： 6595988     DOI： 10.1007/978-3-642-69132-4_34

Source DB:  PubMed          Journal:  Arch Toxicol Suppl        ISSN： 0171-9750


  5 in total

Review 1.  Biochemistry and pharmacology of S-adenosyl-L-methionine and rationale for its use in liver disease.

Authors:  R K Chawla; H L Bonkovsky; J T Galambos
Journal:  Drugs       Date:  1990       Impact factor: 9.546

2.  Mechanism for prevention of alcohol-induced liver injury by dietary methyl donors.

Authors:  Christine L Powell; Blair U Bradford; Christopher Patrick Craig; Masato Tsuchiya; Takeki Uehara; Thomas M O'Connell; Igor P Pogribny; Stepan Melnyk; Dennis R Koop; Lisa Bleyle; David W Threadgill; Ivan Rusyn
Journal:  Toxicol Sci       Date:  2010-01-29       Impact factor: 4.849

3.  Effect of S-adenosyl-L-methionine and dilinoleoylphosphatidylcholine on liver lipid composition and ethanol hepatotoxicity in isolated perfused rat liver.

Authors:  A Gigliozzi; R Romeo; F Fraioli; A Cantafora; M Delle Monache; A Cardilli; A F Attili; E Scafato; L Carli; D Alvaro
Journal:  Dig Dis Sci       Date:  1998-10       Impact factor: 3.199

Review 4.  S-adenosyl-L-methionine. A review of its pharmacological properties and therapeutic potential in liver dysfunction and affective disorders in relation to its physiological role in cell metabolism.

Authors:  H A Friedel; K L Goa; P Benfield
Journal:  Drugs       Date:  1989-09       Impact factor: 9.546

5.  Effect of S-adenosyl-L-methionine on ethanol cholestasis and hepatotoxicity in isolated perfused rat liver.

Authors:  D Alvaro; A Gigliozzi; C Piat; L Carli; A Bini; T La Rosa; S Furfaro; L Capocaccia
Journal:  Dig Dis Sci       Date:  1995-07       Impact factor: 3.199
  5 in total

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