Literature DB >> 6594998

Platelet-activating factor stimulation of peptidoleukotriene release: inhibition by vasoactive polypeptide.

B B Beaubien, J R Tippins, H R Morris.   

Abstract

Leukotriene (LT) release stimulated by platelet activating factor was inhibited by vasoactive intestinal polypeptide (VIP) in an in vitro rat lung preparation. This was detected by HPLC and radioimmunoassay. LTC4, although the major species in the stimulatory model used, was not detected in peptide-treated preparations and LTD4 and LTE4 levels were considerably reduced.

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Year:  1984        PMID： 6594998     DOI： 10.1016/s0006-291x(84)80340-x

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  9 in total

1.  Molecular mapping of epitopes involved in ligand activation of the human receptor for the neuropeptide, VIP, based on hybrids with the human secretin receptor.

Authors:  B Olde; A Sabirsh; C Owman
Journal:  J Mol Neurosci       Date:  1998-10       Impact factor: 3.444

2.  Effect of a 5-lipoxygenase inhibitor and leukotriene antagonist (PF 5901) on PAF-induced airway responses in neonatally immunized rabbits.

Authors:  C M Herd; D Donigi-Gale; T S Shoupe; C P Page
Journal:  Br J Pharmacol       Date:  1992-12       Impact factor: 8.739

3.  Coronary vasoconstriction in the rat, isolated perfused heart induced by platelet-activating factor is mediated by leukotriene C4.

Authors:  P J Piper; A G Stewart
Journal:  Br J Pharmacol       Date:  1986-07       Impact factor: 8.739

4.  Effects of vasoactive intestinal peptide, helodermin and galanin on responses of guinea-pig lung parenchyma to histamine, acetylcholine and leukotriene D4.

Authors:  D M Conroy; M N Samhoun; P J Piper
Journal:  Br J Pharmacol       Date:  1991-12       Impact factor: 8.739

5.  Enhancement of leukotriene B4 release in stimulated asthmatic neutrophils by platelet activating factor.

Authors:  K Shindo; K Koide; M Fukumura
Journal:  Thorax       Date:  1997-12       Impact factor: 9.139

6.  Priming effect of platelet activating factor on leukotriene C4 from stimulated eosinophils of asthmatic patients.

Authors:  K Shindo; K Koide; Y Hirai; M Sumitomo; M Fukumura
Journal:  Thorax       Date:  1996-02       Impact factor: 9.139

7.  Antagonism of vasoconstriction induced by platelet-activating factor in guinea-pig perfused hearts by selective platelet-activating factor receptor antagonists.

Authors:  P J Piper; A G Stewart
Journal:  Br J Pharmacol       Date:  1987-04       Impact factor: 8.739

8.  Effects of vasoactive intestinal polypeptide on antigen-induced bronchoconstriction and thromboxane release in guinea-pig lung.

Authors:  G Ciabattoni; P Montuschi; D Currò; G Togna; P Preziosi
Journal:  Br J Pharmacol       Date:  1993-05       Impact factor: 8.739

Review 9.  Targeting VIP and PACAP Receptor Signaling: New Insights into Designing Drugs for the PACAP Subfamily of Receptors.

Authors:  Jessica Lu; Sarah J Piper; Peishen Zhao; Laurence J Miller; Denise Wootten; Patrick M Sexton
Journal:  Int J Mol Sci       Date:  2022-07-22       Impact factor: 6.208
  9 in total

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