Literature DB >> 6594649

In vitro enhancement of adriamycin cytotoxicity in human myeloid leukemia cells exposed to verapamil.

S G Pradhan, V S Basrur, M P Chitnis, S H Adwani.   

Abstract

The natural resistance of human chronic myeloid leukemia cells to adriamycin (ADR) was overcome by using the cell membrane modulator verapamil (VRP). The studies were done in vitro. [3H] thymidine incorporation inhibition was used as a measure of cytotoxicity. The results clearly show an increase in the effectiveness of ADR when used along with VRP, which may be due to the changes in the cell membrane brought about by VRP.

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Year:  1984        PMID： 6594649     DOI： 10.1159/000225865

Source DB:  PubMed          Journal:  Oncology        ISSN： 0030-2414            Impact factor:   2.935


  4 in total

1.  In vitro synergism between hybrid immunotoxins and chemotherapeutic drugs: relevance to immunotherapy of prostate carcinoma.

Authors:  K S Webb; S N Liberman; J L Ware; P J Walther
Journal:  Cancer Immunol Immunother       Date:  1986       Impact factor: 6.968

2.  Enhancement of the in vitro cytotoxicity of bouvardin by verapamil alone and combined with hyperthermia in Sarcoma 180 and Ehrlich ascites carcinoma cells.

Authors:  M P Chitnis; M K Adwankar
Journal:  J Cancer Res Clin Oncol       Date:  1986       Impact factor: 4.553

3.  Reversal of natural resistance to bouvardin (NSC 259968) in sarcoma 180 cells in vitro and in vivo by verapamil.

Authors:  M P Chitnis; R S Menon; V S Basrur; M K Adwankar; K Satyamoorthy
Journal:  J Cancer Res Clin Oncol       Date:  1985       Impact factor: 4.553

4.  Verapamil potentiation of doxorubicin resistance development in B16 melanoma cells both in vitro and in vivo.

Authors:  F Formelli; R Supino; L Cleris; M Mariani
Journal:  Br J Cancer       Date:  1988-04       Impact factor: 7.640
  4 in total

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