Literature DB >> 6592034

Response of chronic myelogenous leukemia patients to COAP-splenectomy. A Southwest Oncology Group study.

J P Hester, C C Waddell, C A Coltman, F S Morrison, R L Stephens, S P Balcerzak, L H Baker, T T Chen.   

Abstract

Eighty-seven patients from 18 institutions with a confirmed diagnosis of chronic myelogenous leukemia were registered on a Southwest Oncology Group protocol for multiagent induction and single-agent maintenance chemotherapy, with randomization to an immunotherapy arm. Elective surgical splenectomy was performed for 42 patients at the completion of 3 months of induction therapy. Final analysis of the study revealed statistically significant survival advantages were correlated with age, splenectomy, the absence of hepatic leukemic infiltrate at the time of splenectomy, and race.

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Year:  1984        PMID: 6592034     DOI: 10.1002/1097-0142(19841101)54:9<1977::aid-cncr2820540932>3.0.co;2-v

Source DB:  PubMed          Journal:  Cancer        ISSN: 0008-543X            Impact factor:   6.860


  3 in total

1.  Splenic red pulp macrophages provide a niche for CML stem cells and induce therapy resistance.

Authors:  Elias D Bührer; Michael A Amrein; Stefan Forster; Stephan Isringhausen; Christian M Schürch; Salil S Bhate; Tess Brodie; Joel Zindel; Deborah Stroka; Mohamad Al Sayed; César Nombela-Arrieta; Ramin Radpour; Carsten Riether; Adrian F Ochsenbein
Journal:  Leukemia       Date:  2022-09-26       Impact factor: 12.883

2.  Treatment of chronic myelogenous leukemia with recombinant interferon alfa-2b.

Authors:  N Niederle; O Kloke; D May; R Becher; R Osieka; C G Schmidt
Journal:  Invest New Drugs       Date:  1987       Impact factor: 3.850

3.  [Splenectomy: surgical indications in malignant hematologic diseases].

Authors:  F Harder; C Honegger; M Dürig
Journal:  Langenbecks Arch Chir       Date:  1986
  3 in total

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