| Literature DB >> 6591429 |
M J Fargeas, J Fioramonti, L Buéno.
Abstract
Two micrograms of prostaglandin E2 injected into the lateral ventricle of the brain in rats had the same anorectic and gastrointestinal motor effect as central administration of 0.02 unit of calcitonin. The effects of calcitonin were blocked by a previous intracerebroventricular administration of 0.25 milligram of indomethacin. These results suggest that both anorectic and gastrointestinal motor effects of calcitonin are centrally mediated by the release of prostaglandins.Entities:
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Year: 1984 PMID： 6591429 DOI： 10.1126/science.6591429
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728