Literature DB >> 6591184

Abnormal collagen metabolism in cultured skin fibroblasts from patients with Duchenne muscular dystrophy.

H P Rodemann, K Bayreuther.   

Abstract

Total collagen synthesis is decreased by about 29% (P less than 0.01) in skin fibroblasts established in vitro from male patients with Duchenne muscular dystrophy (DMD) as compared with that in normal male skin fibroblasts in vitro. The reduction in collagen synthesis is associated with an approximately 2-fold increase in collagen degradation in DMD fibroblasts. Correlated to these alterations in the metabolism of collagen, DMD fibroblasts express a significantly higher hydroxyproline/proline ratio (DMD: 1.36-1.45; P less than 0.01) than do normal fibroblasts (controls: 0.86-0.89). The increased hydroxylation of proline residues of collagen (composed of type I and type III) could be the cause for the enhanced degradation of collagen in DMD fibroblasts.

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Year:  1984        PMID： 6591184      PMCID： PMC391651          DOI： 10.1073/pnas.81.16.5130

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  35 in total

1.  Structure of 18S and 14S acetylcholinesterase. Identification of collagen-like subunits that are linked by disulfide bonds to catalytic subunits.

Authors:  T L Rosenberry; J M Richardson
Journal:  Biochemistry       Date:  1977-08-09       Impact factor: 3.162

2.  (Alpha1(3))3 human skin collagen. Release by pepsin digestion and preponderance in fetal life.

Authors:  E H Epstein
Journal:  J Biol Chem       Date:  1974-05-25       Impact factor: 5.157

3.  In vitro enzymatic hydroxylation of prolyl residues in the alpha 1-CB2 fragment of rat collagen.

Authors:  R E Rhoads; S Udenfriend; P Bornstein
Journal:  J Biol Chem       Date:  1971-07-10       Impact factor: 5.157

4.  Fibroblasts degrade newly synthesised collagen within the cell before secretion.

Authors:  R S Bienkowski; B J Baum; R G Crystal
Journal:  Nature       Date:  1978-11-23       Impact factor: 49.962

5.  Erythrocyte membrane autophosphorylation in Duchenne muscular dystrophy: effect of two methods of erythrocyte ghost preparation on results.

Authors:  A D Roses
Journal:  Clin Chim Acta       Date:  1979-07-02       Impact factor: 3.786

6.  Increased membrane permeability to chloride in Duchenne muscular dystrophy fibroblasts and its relationship to muscle function.

Authors:  C N Pato; M H Davis; M J Doughty; S H Bryant; E Gruenstein
Journal:  Proc Natl Acad Sci U S A       Date:  1983-08       Impact factor: 11.205

7.  Electron spin resonance investigations of membrane proteins in erythrocytes in muscle diseases. Duchenne and myotonic muscular dystrophy and congenital myotonia.

Authors:  D A Butterfield
Journal:  Biochim Biophys Acta       Date:  1977-10-03

8.  Carbohydrate content of insoluble elastins prepared from adult bovine and calf ligamentum nuchae and tropoelastin isolated from copper-deficient porcine aorta.

Authors:  M E Grant; F S Steven; D S Jackson; L B Sandberg
Journal:  Biochem J       Date:  1971-01       Impact factor: 3.857

9.  A spin label study of the erythrocyte membranes in Duchenne muscular dystrophy.

Authors:  M Laurent; D Daveloose; F Leterrier; S Fischer; G Schapira
Journal:  Clin Chim Acta       Date:  1980-08-04       Impact factor: 3.786

10.  Factors influencing osmotic fragility of red blood cells in Duchenne muscular dystrophy.

Authors:  H D Kim; M G Luthra; R P Watts; L Z Stern
Journal:  Neurology       Date:  1980-07       Impact factor: 9.910
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  5 in total

Review 1.  The progression of renal diseases: on the pathogenesis of renal interstitial fibrosis.

Authors:  G A Müller; J Markovic-Lipkovski; H P Rodemann
Journal:  Klin Wochenschr       Date:  1991-09-03

2.  Differential degradation of [35S]methionine polypeptides in Duchenne muscular dystrophy skin fibroblasts in vitro.

Authors:  H P Rodemann; K Bayreuther
Journal:  Proc Natl Acad Sci U S A       Date:  1986-04       Impact factor: 11.205

3.  Human skin fibroblasts in vitro differentiate along a terminal cell lineage.

Authors:  K Bayreuther; H P Rodemann; R Hommel; K Dittmann; M Albiez; P I Francz
Journal:  Proc Natl Acad Sci U S A       Date:  1988-07       Impact factor: 11.205

4.  Upregulation of GADD45α in light-damaged retinal pigment epithelial cells.

Authors:  M-L Gao; W-L Deng; N Huang; Y-Y Wang; X-L Lei; Z-Q Xu; D-N Hu; J-Q Cai; F Lu; Z-B Jin
Journal:  Cell Death Discov       Date:  2016-02-29

5.  Urethral injection of dedifferentiated fat cells ameliorates sphincter damage and voiding dysfunction in a rat model of persistence stress urinary incontinence.

Authors:  Yasutaka Murata; Daisuke Obinata; Taro Matsumoto; Yuichiro Ikado; Koichiro Kano; Noboru Fukuda; Kenya Yamaguchi; Satoru Takahashi
Journal:  Int Urol Nephrol       Date:  2022-02-17       Impact factor: 2.370
  5 in total

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