Literature DB >> 6589859

The fate of the phagosome: conversion to 'age pigment' and impact in human retinal pigment epithelium.

L Feeney-Burns, G E Eldred.   

Abstract

Phagosomes are converted to phagolysosomes and then to residual bodies (also known as lipofuscin granules or age pigment). Lipofuscin granules of retinal pigment epithelial (RPE) cells of single human eyes were isolated and analysed for enzyme content and fluorescence spectra. The granules are low in lysosomal enzymes and they fluoresce yellow-gold. Thin layer chromatography reveals several separable constituents. Lipofuscin granules accumulate with age, the largest increase occurring after the first decade of life in humans. Macular RPE cells accumulate granules more than non-macular cells.

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Year:  1983        PMID： 6589859

Source DB:  PubMed          Journal:  Trans Ophthalmol Soc U K        ISSN： 0078-5334


  41 in total

1.  Quantitative evaluation of fundus autofluorescence imaged "in vivo" in eyes with retinal disease.

Authors:  N Lois; A S Halfyard; A C Bird; F W Fitzke
Journal:  Br J Ophthalmol       Date:  2000-07       Impact factor: 4.638

2.  Spectroscopic and morphological studies of human retinal lipofuscin granules.

Authors:  Nicole M Haralampus-Grynaviski; Laura E Lamb; Christine M R Clancy; Christine Skumatz; Janice M Burke; Tadeusz Sarna; John D Simon
Journal:  Proc Natl Acad Sci U S A       Date:  2003-02-28       Impact factor: 11.205

3.  Fundus autofluorescence imaging compared with different confocal scanning laser ophthalmoscopes.

Authors:  C Bellmann; G S Rubin; S A Kabanarou; A C Bird; F W Fitzke
Journal:  Br J Ophthalmol       Date:  2003-11       Impact factor: 4.638

Review 4.  Therapeutic targets in age-related macular disease.

Authors:  Alan C Bird
Journal:  J Clin Invest       Date:  2010-09-01       Impact factor: 14.808

Review 5.  The retinal pigment epithelium in health and disease.

Authors:  J R Sparrow; D Hicks; C P Hamel
Journal:  Curr Mol Med       Date:  2010-12       Impact factor: 2.222

6.  Fundus autofluorescence in exudative age-related macular degeneration.

Authors:  Vikki A McBain; John Townend; Noemi Lois
Journal:  Br J Ophthalmol       Date:  2006-09-06       Impact factor: 4.638

7.  Müller cell alterations from long-term ambient fluorescent light exposure in monkeys: light and electron microscopic, fluorescein and lipofuscin study.

Authors:  D K Berler
Journal:  Trans Am Ophthalmol Soc       Date:  1989

Review 8.  Retinal photodamage mediated by all-trans-retinal.

Authors:  Tadao Maeda; Marcin Golczak; Akiko Maeda
Journal:  Photochem Photobiol       Date:  2012-04-24       Impact factor: 3.421

9.  The lipofuscin component A2E selectively inhibits phagolysosomal degradation of photoreceptor phospholipid by the retinal pigment epithelium.

Authors:  Silvia C Finnemann; Lawrence W Leung; Enrique Rodriguez-Boulan
Journal:  Proc Natl Acad Sci U S A       Date:  2002-03-19       Impact factor: 11.205

10.  Lipofuscin accumulation, abnormal electrophysiology, and photoreceptor degeneration in mutant ELOVL4 transgenic mice: a model for macular degeneration.

Authors:  G Karan; C Lillo; Z Yang; D J Cameron; K G Locke; Y Zhao; S Thirumalaichary; C Li; D G Birch; H R Vollmer-Snarr; D S Williams; K Zhang
Journal:  Proc Natl Acad Sci U S A       Date:  2005-03-04       Impact factor: 11.205
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