Literature DB >> 6589038

Intraosseously transplantable osteosarcoma with regularly disseminating pulmonary metastases in rats.

F Wingen, D Schmähl, M R Berger, H Spring.   

Abstract

An intratibially transplantable osteogenic sarcoma in rats, that regularly disseminates osteogenic metastases in the lung, is described. The tumor take rates exceeded 90% 30 days after transplantation. Pulmonary metastases were diagnosed in about 99% of the animals, while metastases in the kidneys (14%), lymph nodes (13%) and liver (3%) occurred less frequently. The mean survival time of untreated animals varied between 36 and 48 days, depending on the age at transplantation. Histologic and scintigraphic findings are reported.

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Year:  1984        PMID: 6589038     DOI: 10.1016/0304-3835(84)90155-1

Source DB:  PubMed          Journal:  Cancer Lett        ISSN: 0304-3835            Impact factor:   8.679


  8 in total

1.  Sensitivity of rodent osteosarcoma clones to platinum-containing phosphonic acid complexes in vitro.

Authors:  T Klenner; P Valenzuela-Paz; B K Keppler; H R Scherf
Journal:  J Cancer Res Clin Oncol       Date:  1990       Impact factor: 4.553

2.  In vivo and in vitro investigations on biological effects of aromatic bis-(2-chloroethyl)amino-bisphosphonic acids, new agents proposed for chemotherapy of bone tumors: cytostatic activity in rat osteosarcoma; toxicity and genotoxicity in liver and bone marrow; mutagenicity in S. typhimurium.

Authors:  B L Pool; M Berger; J R Schlehofer; F Wingen
Journal:  Invest New Drugs       Date:  1988-06       Impact factor: 3.850

3.  Anticancer-agent-linked phosphonates with antiosteolytic and antineoplastic properties: a promising perspective in the treatment of bone-related malignancies?

Authors:  T Klenner; F Wingen; B K Keppler; B Krempien; D Schmähl
Journal:  J Cancer Res Clin Oncol       Date:  1990       Impact factor: 4.553

4.  Therapeutic efficacy of two different cytostatic-linked phosphonates in combination with razoxane in the transplantable osteosarcoma of the rat.

Authors:  T Klenner; F Wingen; B Keppler; P Valenzuela-Paz; F Amelung; D Schmähl
Journal:  Clin Exp Metastasis       Date:  1990 Jul-Aug       Impact factor: 5.150

5.  Synthesis, antitumor activity, distribution and toxicity of 4-[4-[bis(2-chloroethyl)amino]phenyl]-1-hydroxybutane-1 1-bisphosphonic acid (BAD), a new lost derivative with increased accumulation in rat osteosarcoma.

Authors:  F Wingen; H Sterz; H Blum; H Möller; W Pittermann; B L Pool; H J Sinn; H Spring; D Schmähl
Journal:  J Cancer Res Clin Oncol       Date:  1986       Impact factor: 4.553

6.  Changing metastatic patterns of a transplantable rat osteosarcoma.

Authors:  F Wingen; E Weber
Journal:  Clin Exp Metastasis       Date:  1987 Jan-Mar       Impact factor: 5.150

7.  Antimetastatic effects of razoxane in a rat osteosarcoma model.

Authors:  F Wingen; H Spring; D Schmähl
Journal:  Clin Exp Metastasis       Date:  1987 Jan-Mar       Impact factor: 5.150

8.  Effects of new bisphosphonic acids on tumor-induced bone destruction in the rat.

Authors:  F Wingen; T Eichmann; C Manegold; B Krempien
Journal:  J Cancer Res Clin Oncol       Date:  1986       Impact factor: 4.553

  8 in total

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